Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. [5][6] This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and cardiac atrial muscle (MYL7).

Myosin Light Chain 2 Antibody detects endogenous levels of total Myosin Light Chain 2 (smooth muscle). This antibody does not cross-react with the cardiac isoform of Myosin Light Chain 2, or Myosin Essential Light Chain.

Myosin light chains (MLCs) can be broadly classified into two groups: Regulatory MLC (MLC2 or RLC). Essential and regulatory MLCs have molecular masses of 22 and 19 kDa, respectively. Structurally, MLC2 contains a serine residue that is lacking in MLC1.

Myosin light chain-2 (MYL2, also called MLC-2) is an ∼19 kDa sarcomeric protein that belongs to the EF-hand calcium binding protein superfamily and exists as three major isoforms encoded by three distinct genes in mammalian striated muscle.

2024年12月25日 · MYL2 (Myosin Light Chain 2) is a Protein Coding gene. Diseases associated with MYL2 include Cardiomyopathy, Familial Hypertrophic, 10 and Myopathy, Myofibrillar, 12, Infantile-Onset, With Cardiomyopathy. Among its related pathways are Activation of cAMP-Dependent PKA and Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases.

Myosin light chain 2 (MLC2), also known as myosin regulatory light chain (MRLC), RLC, or LC20, has many isoforms depending on its distribution. In smooth muscle, MLC2 is phosphorylated at Thr18 and Ser19 by myosin light chain kinase (MLCK) in a …

2021年10月6日 · Approximately 40% of cardiac myosin RLC (also referred to as myosin light chain 2, MLC2) is phosphorylated, and this level remains relatively constant in the normal hearts of various animals ...