MECP2 (methyl CpG binding protein 2) is a gene [5] that encodes the protein MECP2. [6] MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in high levels.

MECP2 duplication syndrome is a rare neurodevelopmental condition caused by an extra copy (duplication) of the MECP2 gene. The disorder can cause a wide range of symptoms with varying severity.

2024年12月25日 · MECP2 (Methyl-CpG Binding Protein 2) is a Protein Coding gene. Diseases associated with MECP2 include Rett Syndrome and Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations. Among its related pathways are Transcriptional Regulation by MECP2 and Gene expression (Transcription).

MeCP2基因研究概况. MeCP2对哺乳动物的学习记忆能力有着重要的影响，同时也是 Rett综合症 和 MeCP2重复综合症 的致病基因。MeCP2通过多种机制对基因的转录有显著影响，而且有明确表型的学习和记忆动物模型，使MeCP2成为学习和记忆中基因转录研究的理想对象。

The MECP2 gene provides instructions for making a protein called MeCP2. This protein helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout the body, although it is particularly abundant in brain cells.

2024年8月20日 · Methyl-CpG-binding protein 2 (MeCP2) is an essential chromatin-binding protein whose mutations cause Rett syndrome (RTT), a severe neurological disorder that primarily...

2020年6月19日 · Our findings indicate that MeCP2 interacts with genomic loci via binding to DNA as well as histones, and that interaction between MeCP2 and histone proteins plays a key role in gene expression...

近日，来自MIT的Richard A. Young课题组在Nature杂志发表了题为MeCP2 links heterochromatin condensates and neurodevelopmental disease 的文章，从 相分离 的角度阐述了MeCP2突变导致Rett综合征的可能原因，为该疾病的治疗手段的开发，提供了新的思路。

MECP2转录后形成MECP2-e1和MECP2-e2两种剪切体 。MECP2有3个主要的功能域：CpG结合域（methyl-CpG-bingding domain, MBD）、转录抑制域（transcription repression domain, TRD）和C-末端域（C-termianl domain, CTD）。

MeCP2（Methyl-CpG Binding Protein 2）基因是位于X染色体上的一个重要基因，编码一种结合甲基化CpG二核苷酸的蛋白质。 这种蛋白质在调控基因表达、维持染色质结构和调控神经元功能中起关键作用。