Dec 25, 2024 · MBD2 (Methyl-CpG Binding Domain Protein 2) is a Protein Coding gene. Diseases associated with MBD2 include Klatskin's Tumor and Tetralogy Of Fallot. Among its …

Jul 13, 2023 · These findings suggest that Mbd2 is a novel epigenetic regulator of genes that are associated with ASD in humans. Mbd2 loss causes behavioral alterations that resemble those …

MBD2 seems to play a selective role in gene repression depending on the CpG content of the promoter region; Methylated DNA binding domain protein 2 (MBD2) coordinately silences …

Jun 29, 2023 · Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of the NuRD complex. …

MBD2 has been linked to immune system function and tumorigenesis, yet little is known about its functions in vivo. Recent studies have found the MBD2 protein is ubiquitously expressed, with …

Dec 9, 2014 · This review focuses on two members of the methyl binding proteins, namely MBD2 and MBD3 that reside in very similar complexes, yet appear to have very different biological …

Apr 1, 2024 · MBD2 was found to control several genes involved in how cancer progresses and how the immune system responds.

MBD2 is a transcriptional repressor that specifically binds to methylated DNA and is a component of the MeCP1 protein complex. In contrast, MBD3 fails to bind methylated DNA in murine cells, …

MBD2 aggravates pulmonary fibrosis by enhancing TGF-β/Smad signaling. MBD2 promotes Th17 cell differentiation by downregulating SOCS3 expression. MBD2 inhibits the expression of …

Feb 8, 2025 · Mbd2, which recruits co-repressor complexes to methylated DNA, is essential for efficient tumorigenesis in the intestine. MBDin relieves MBD2 repression potential and …