The mannose 6-phosphate receptors (MPRs) are transmembrane glycoproteins that target enzymes to lysosomes in vertebrates. [1] Mannose 6-phosphate receptors bind newly synthesized lysosomal hydrolases in the trans-Golgi network (TGN) and deliver them to …

Dec 25, 2024 · M6PR (Mannose-6-Phosphate Receptor, Cation Dependent) is a Protein Coding gene. Diseases associated with M6PR include Pompe Disease and Niemann-Pick Disease. Among its related pathways are Sphingolipid metabolism and Vesicle-mediated transport.

阳离子非依赖性甘露糖 6-磷酸受体 (CI-M6PR) 是一种普遍存在的跨膜受体，其主要细胞内作用是将携带甘露糖 6-磷酸部分的酶引导至溶酶体区室。 最近，该受体的小膜结合部分似乎与许多病理生理过程有关。 本综述概述了 CI-M6PR 的主要配体伙伴以及在溶酶体贮积病 、神经病学、免疫学和癌症领域中的作用。 此外，这种膜受体因其细胞内化活性和将致病因子降解至溶酶体的能力而因其在治疗应用中的强大潜力而闻名。 目前正在提出许多使用 CI-M6PR 的治疗递送方法，特别是 …

Jan 1, 2024 · The cation-independent mannose 6-phosphate receptor (CI-M6PR) is a ubiquitous transmembrane receptor whose main intracellular role is to direct enzymes carrying mannose 6-phosphate moieties to lysosomal compartments. Recently, the small membrane-bound portion of this receptor has appeared to be implicated in numerous pathophysiological processes.

May 16, 2018 · We propose that targeting kinesin motor KIF13A and M6PR has great potential for vaccine design and efficient immunotherapy.

CI-M6PR has been proposed as an alternative pathway to induce cell death through the delivery of lymphocyte granule toxins. Several studies indicate that CI-M6PR expressed at the cell membrane binds to granzyme B, a serine protease, secreted by cytotoxic T lymphocytes and natural killer cells, via its M6P moiety and induces endocytosis . In the ...

Apr 25, 2017 · Mannose-6-phosphate receptor (M6PR) that facilitates cellular uptake of M6P-bearing proteins, including serine-protease granzyme-B (Gzm-B) has an important role in...

In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene. [5] [6]The CD-MPR is one of two transmembrane proteins that bind mannose-6-phosphate (M6P) tags on acid hydrolase precursors in the Golgi apparatus that are destined for ...

Sortilin is a new alpha-Gal A receptor expressed in renal endothelial cells and that this receptor together with the M6PR is able to internalize circulating alpha-Gal A. Mannose receptor (MR) engagement by mesothelin GPI anchor polarizes tumor-associated macrophages and is blocked by anti-MR human recombinant antibody

P 型凝集素通过将含 6-磷酸甘露糖的酸性水解酶从高尔基复合体特异性转运至溶酶体，在溶酶体功能中发挥关键作用。 编码的蛋白质作为同型二聚体发挥作用，需要二价阳离子才能与配体结合。 已经观察到该基因编码多种亚型的可变剪接转录物变体。 该基因的一个假基因位于 X 染色体的长臂上。 [RefSeq 提供，2011 年 5 月] This gene encodes a member of the P-type lectin family.