Feb 21, 2021 · Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions, especially in the initiation and progression of …

Dec 12, 2024 · N6-methyladenosine (m6A) is an mRNA modification influencing gene expression. Advanced methodologies for mapping m6A enhance understanding of its dynamic roles and …

Sep 13, 2019 · RNA methylation to form N 6 -methyladenosine (m 6 A) in mRNA accounts for the most abundant mRNA internal modification and has emerged as a widespread regulatory …

Feb 1, 2021 · We highlight advances in our understanding of the regulation of m 6 A deposition on mRNA and its context-dependent effects on mRNA decay and translation, the role of m 6 A …

We highlight advances in our understanding of the regulation of m 6 A deposition on mRNA and its context‐dependent effects on mRNA decay and translation, the role of m 6 A methylation of …

Mar 12, 2025 · N6-methyladenosine (m6A) is a prevalent and conserved RNA modification in eukaryotes. While its roles in the 3’ untranslated regions (3’ UTR) are well-studied, its role in …

Feb 21, 2021 · N 6 -methyladenosine (m6A) is the most prevalent, abundant and conserved internal cotranscriptional modification in eukaryotic RNAs, especially within higher eukaryotic …

Jan 29, 2022 · Here, we review the general role of m6A, highlighting recent advances related to the three major types enzymes that determine the level of m6A modification (i.e., writers, …

Of note, m6A mRNA granules have been observed within 30 minutes of heat shock. Thus, some m6A mRNAs may still be preferentially enriched in these granules for storage rather than …

3 days ago · Purpose N6-methyladenosine (m6A) is the most prevalent base epigenetic modification within eukaryotic mRNAs. It participates in post-transcriptional regulation, …

Sep 17, 2020 · Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. It has been found that the effect …

Sep 9, 2024 · Brown adipose tissue (BAT) regulates systemic metabolism by releasing signaling lipids. N 6 -methyladenosine (m 6 A) is the most prevalent and abundant post-transcriptional …

m 6 A is a reversible modification in mRNA (reviewed in ), meaning that distinct sets of proteins introduce (writers), recognize (readers) and remove (erasers) this mark, allowing it to exert …

Mar 12, 2025 · Results: We demonstrate that m 6 A methylation in the 5' UTR of mRNA triggers a downstream shift in H3K4me3 modification. This regulatory mechanism is conserved in …

As the most prevalent internal modification in mRNA, N 6-methyladenosine (m6A) plays broad biological functions via fine-tuning gene expression at the post-transcription level. Such …

Mar 25, 2022 · The mRNA of Nfkbia, the NF-κB inhibitor, is the direct target of m 6 A modification. Thus, depletion of m 6 A modification led to enhanced stability of Nfkbia mRNA and …

Feb 15, 2024 · Here we dissect the determinants governing RNA methylation via interspecies and intraspecies hybrids in yeast and mammalian systems, coupled with massively parallel …

Mar 10, 2025 · Here, we demonstrated that a critical m6A reader, insulin like growth Factor 2 mRNA binding protein 3 (IGF2BP3) directly recognized m6A modified mRNAs of MCM10 gene …

Feb 2, 2023 · Here, we review RNA m6A modification in the light of the recent appreciation of nuclear roles for m6A in regulating chromatin states and gene expression, as well as the …

3 days ago · The m6A level of YPEL3 mRNA was analyzed using the Magna MeRIP m6A Kit (Millipore, Billerica, MA, USA). Briefly, RNA was extracted from THLE-2 and AML12 cells and …

Jun 16, 2022 · In this review, Murakami et al. discuss the recently recognized concept of epitranscriptomic regulation with a focus on N6-methyladenosine (m6A), the most abundant …

N6-methyladenosine (m6A) is the most frequent chemical modification in eukaryotic mRNA and is known to participate in a variety of physiological processes, including cancer progression and …

Though N6 -methyladenosine (m 6 A) modification has been well known to affect the fate of messenger RNA (mRNA), whether it plays a role in regulating plant immunity remained …

Jan 20, 2021 · We highlight advances in our understanding of the regulation of m 6 A deposition on mRNA and its context‐dependent effects on mRNA decay and translation, the role of m 6 A …

Geula et al. now show that N6-methyladenosine (m6A), a messenger RNA (mRNA) modification present on transcripts of pluripotency factors, drives this transition. Methylation destabilized …

Mar 11, 2025 · Background The screening and monitoring of gastric cancer is still a clinical challenge. Both N6-methyladenosine (m6A) and lncRNAs have been evidenced as critical …

Sep 21, 2023 · As the most common internal post-transcriptional RNA modification in eukaryotic cells, N6-methyladenosine (m 6 A) performs a dynamic and reversible role in a variety of …