The LX-2 cell line retains key features of cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis.

LX-2 was generated by immmortalization of primary human hepatic stellate cells with the SV40 large T antigen followed by selective culture of early passaged cells in low serum media conditions.

LX-2 cells are used to examine the cellular and molecular mechanisms underlying liver fibrosis, including the role of stellate cells in extracellular matrix deposition and the modulation of these processes by therapeutic agents.

Human hepatic stellate cell line (LX-2) exhibits characteristics of bone marrow-derived mesenchymal stem cells. Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. Genetic characteristics of the human hepatic stellate cell line LX-2.

The LX-2 human hepatic stellate cell line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis , making them a highly suitable model of human hepatic fibrosis.

Serum-Free media adapted LX-2 human hepatic stellate cells that been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis , making them a highly suitable model of human hepatic fibrosis. Key Applications: Stem Cell Culture; Cell Culture ...

2013年10月8日 · LX-2 cells were first introduced in 2003 and initially characterized in 2005 as a low-passaged human cell line derived from normal human stellate cells that are spontaneously immortalized. Cells were originally selected by their ability to grow under low serum conditions.

Conclusions: LX-1 and LX-2 human HSC lines provide valuable new tools in the study of liver disease. Both lines retain key features of HSCs. Two unique advantages of LX-2 are their viability in serum free media and high transfectability.

MilliporeSigma™ LX-2 Human Hepatic Stellate Cell Line LX-2 Human Hepatic Stellate Cell Line has been extensively characterized and retain key features of hepatic stellate cytokine signaling, neuronal gene expression, retinoid metabolism, and fibrogenesis , making them a highly suitable model of human hepatic fibrosis.

LX-2 is a human hepatic stellate cell line that has become a standard model for studying liver fibrosis. This cell line was immortalized from primary human hepatic stellate cells, retaining many of the in vivo characteristics