Lipid rafts influence membrane fluidity and membrane protein trafficking, thereby regulating neurotransmission and receptor trafficking. [3] [6] Lipid rafts are more ordered and tightly packed than the surrounding bilayer, but float freely within the membrane bilayer. [7]

Lipid rafts are plasma membrane microdomains rich in cholesterol and sphingolipids, providing an ordered lipid environment. They are crucial for neural development and function, acting as platforms for signal transduction, cell adhesion, axon guidance, and synaptic transmission in …

Here, we focus on discussing newly discovered functions of lipid rafts and microdomains in intracellular membranes, including lipid and protein trafficking from the ER, Golgi bodies, and endosomes to the PM, and we examine lipid raft involvement in …

Lipid rafts in the plasma membrane function as a concentrating platform for different receptors and consequently regulate a plethora of functions, including intra-cellular signalling, interaction with the extracellular milieu, and proliferation.

Lipid rafts are dynamic assemblies of proteins and lipids that float freely within the liquid-disordered bilayer of cellular membranes but can also cluster to form larger, ordered platforms. Rafts are receiving increasing attention as devices that regulate membrane function in …

In a simplified way, lipid rafts are solid regions of plasma membrane embedded into (or floating in) predominantly fluid membrane. They are small and often short-lived; they are heterogeneous in just about any parameter, and yet, they are distinct.

Recent studies from our lab and others have indicated an important role for lipid rafts in axonal growth and guidance. Specifically, our data show that lipid rafts on the plasma membrane provide platforms for spatial and temporal control of guidance signaling by extracellular cues.

2017年3月30日 · Lipid rafts are relatively ordered membrane domains that are enriched in cholesterol and saturated lipids, and selectively recruit other lipids and proteins.

2020年5月1日 · Here, we focus on discussing newly discovered functions of lipid rafts and microdomains in intracellular membranes, including lipid and protein trafficking from the ER, Golgi bodies, and endosomes to the PM, and we examine lipid raft involvement in the production and composition of EVs.

These microdomains are usually called lipid rafts, and many papers have suggested that rafts play a role in a wide range of important biological processes, including numerous signal transduction pathways, apoptosis, cell adhesion and migration, synaptic transmission, organization of the cytoskeleton, and protein sorting during both exocytosis ...