In molecular biology lin-4 is a microRNA (miRNA) that was identified from a study of developmental timing in the nematode Caenorhabditis elegans. [1] [2] It was the first to be …

1993年12月3日 · lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 …

Our fundamental understanding of miRNA mechanisms arose from studying lin-4 in the simple nematode Caenorhabditis elegans (C. elegans).

1993年12月3日 · lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 …

In this study, we characterized the expression of endogenous lin-4 and found that temporally regulated independent transcripts, but not constitutive lin-4 containing RNAs derived from an …

1993年12月3日 · lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 …

Here, we monitor the dynamics of lin-14 mRNA and protein as well as lin-4 miRNA levels in finely staged animals during early larval development.

2012年6月12日 · Our results show that lin-4 microRNA acts as a potent and specific negative regulator of UNC-6–mediated attraction without affecting SLT-1–mediated repulsion, and we …

1999年12月15日 · lin-4 encodes a small RNA that is complementary to sequences in the 3′ untranslated region (UTR) of lin-14 mRNA and that acts to developmentally repress the …

lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by negatively regulating the level of LIN-14 protein, creating a …