Leukocyte immunoglobulin-like receptor subfamily B member 1 is a protein that in humans is encoded by the LILRB1 gene. [3][4] This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4.

2024年12月25日 · LILRB1 (Leukocyte Immunoglobulin Like Receptor B1) is a Protein Coding gene. Diseases associated with LILRB1 include Human Cytomegalovirus Infection and Malaria. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

LILRs are either activating (LILRA) or inhibitory (LILRB) depending on their associated signalling domains (D). With the exception of the soluble LILRA3, LILRAs mediate immune activation, while LILRB1-5 primarily inhibit immune responses and mediate tolerance.

2025年2月8日 · LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. Leukocyte immunoglobulin-like receptor B1 (LILRB1) protects human multiple myeloma cells from ferroptosis by maintaining cholesterol homeostasis.

Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1–5) transduce signals via intracellular immunoreceptor tyrosine-based inhibitory motifs that recruit phosphatases to negatively regulate immune activation. The activation of LILRB signaling …

2024年7月9日 · Here, we show that the leukocyte immunoglobulin-like receptor B1 (LILRB1), a transmembrane receptor conducting negative immune response, is a top-ranked gene associated with poor...

2023年9月12日 · LILRB1 ligation hampers lysis of cancer cells induced by NK cell lysis receptors such as NKG2D or by activation of FcγRIIIA through therapeutic antibodies targeting a tumor-expressed antigen. LILRB1 antibody blockade enhances cytokine release, natural cytotoxicity and …