2024年12月25日 · LHX6 (LIM Homeobox 6) is a Protein Coding gene. Diseases associated with LHX6 include Geotrichosis and Stuttering. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is LHX8.

2017年8月23日 · Here we show that a subset of GABAergic neurons in the mouse ventral zona incerta, which express the LIM homeodomain factor Lhx6 and are activated by sleep pressure, both directly inhibit...

2024年10月22日 · Lhx6 is essential for mitochondrial homeostasis via tuning PINK1/Parkin-mediated mitophagy and MAPK signaling pathways. Downregulation of Lhx6 by RA transcriptionally disturbs the mitochondrial homeostasis, which in turn leads to the proliferation and migration defect in HEPM cells, ultimately causi …

LHX6 is essential for the migration of human pluripotent stem cell-derived GABAergic interneurons Protein Cell . 2020 Apr;11(4):286-291. doi: 10.1007/s13238-019-00686-6.

Based on hPSC neural differentiation, we describe the role of LHX6 in human GABA interneuron migration by using knockout/overexpression strategies. In this study, we found that LHX6 is critical for controlling human GABAergic interneuron migration, which is confirmed with previous studies from lhx6 transgenic rodents (Liodis et al., 2007). The ...

Known Lhx6 and -8 functions and targets are outlined in neurogenesis, craniofacial development, and germ cell differentiation. The underlying mechanisms of Lhx6 and -8 in regulating cell fate remain elusive.

2025年1月4日 · LHX6 is a putative tumour suppressor gene with epigenetic silencing in lung cancer. LHX6 is a transcriptional repressor that interacts with pituitary homeobox 2 (PITX2) to regulate odontogenesis; found positive association of LHX6 with Tourette syndrome in some European populations, not others.

Lhx6, a LIM-homeodomain transcription factor, is essential for specification of MGE-derived somatostatin and parvalbumin interneurons. Here, we demonstrate that some Lhx6 −/− MGE cells acquire a CGE-like fate.

2021年1月21日 · Here, we show that Lhx6 is necessary for the survival of hypothalamic neurons. Dlx1/2, Nkx2-2, and Nkx2-1 are each required for specification of spatially distinct subsets of hypothalamic...

In this review, we first summarize Lhx6 and -8 distributions in development and then explore how Lhx6 and -8 act as transcription factors and coregulators of cell lineage specification. Known Lhx6 and -8 functions and targets are outlined in neurogenesis, craniofacial development, and germ cell …