The let-7 microRNA family refers to the many slight variations of let-7 that exist both within a single organism and across species. In humans, for example, there are ten unique let-7 family member sequences: let-7 a through g , let-7i , mir-98 , and mir-202 .

2008年10月1日 · let-7 remains one of the key miRNA regulators in development and cancer. The let-7-family miRNAs are highly conserved across animal species in sequence, at what developmental stage they are expressed and in their organization as clusters or within specific coding genes in the genome.

Let-7 miRNAs generally function as tumor suppressors to target multiple oncogenes, including RAS, HMGA2, c-Myc and CCND1. Let-7 miRNAs also function as important immune regulators to control cytokine- and chemokine-mediated inflammatory responses.

The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis elegans, and its biological functions show a high level of evolutionary conservation from the nematode to the human. Unlike in C. elegans, higher animals have ...

Moreover, the direct interaction between miRNAs has recently been identified as a novel pathway to control let-7 expression. In this review, we discuss the multifaceted roles of let-7 and provide an overview of its regulation at multiple levels.

Here, we review let-7-family conservation and the recent advances in understanding how let-7-expression is regulated at the transcriptional and post-transcriptional levels across species. A greater understanding of what controls let-7 expression might enable the development of treatments to fight or prevent many cancers.

Let - 7 targets include genes regulating the cell cycle, cell signaling, and maintenance of differentiation. It is categorized as a tumor suppressor because it reduces cancer aggressiveness, chemoresistance, and radioresistance.

2019年8月28日 · The miRNA let-7 (MIRLET7) family controls developmental timing and differentiation. Let-7 loss contributes to carcinogenesis via an increase in its target oncogenes and stemness factors. Let-7 targets include genes regulating the cell cycle, cell signaling, and maintenance of differentiation.

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans

2015年9月23日 · Let-7 (lethal-7) was one of the first miRNAs to be discovered. It was originally identified as a regulator of developmental timing in the nematode, C. elegans, and was therefore regarded as a heterochronic gene (Reinhart et al., 2000).