Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1), also known as extracellular link domain containing 1 (XLKD1) is a Link domain-containing hyaladherin, a protein capable of binding to hyaluronic acid (HA), homologous to CD44, the main HA receptor. [5]

LYVE-1 (Lymphatic Vessel Endothelial Receptor 1) is a CD44 homolog found primarily on lymphatic endothelial cells. 1 While LYVE-1 functions continue to be defined, potential roles have been suggested in hyaluronan (HA) transport and turnover, or in promoting HA localization to the surfaces of lymphatic endothelium. In addition, several studies ...

2024年12月25日 · LYVE1 (Lymphatic Vessel Endothelial Hyaluronan Receptor 1) is a Protein Coding gene. Diseases associated with LYVE1 include Intramuscular Hemangioma and Complete Androgen Insensitivity Syndrome. Among its related pathways are Glycosaminoglycan metabolism and Metabolism.

LYVE-1, a close relative of the leucocyte receptor, CD44, is the main receptor for hyaluronan (HA) in lymphatic vessel endothelium and a widely used marker for distinguishing between blood and lymphatic vessels.

2001年6月1日 · In a search for novel HA receptors related to CD44, we recently identified an ortholog, LYVE-1, which is expressed predominantly on lymphatic endothelium and is thus a candidate for binding HA and regulating cell migration within the lymphatic system.

2025年2月8日 · LYVE-1 indicates an increase of lymphangiogenesis in colorectal carcinoma. A study using specific markers of endothelium (CD31) and lymphatic endothelial cells (Lyve-1, Podoplanin) shows that not only angiogenesis but also …

1999年2月22日 · However, unlike CD44, the LYVE-1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves.

2025年2月11日 · This study provides the first evidence that the hyaloid vascular system contains a LYVE-1(+) cellular component in both physiological and pathologic conditions. Immunostaining for the specific lymphatic markers LYVE-1 revealed an extensive lymphatic vessel system in …

One such marker, LYVE-1, the lymphatic receptor for the extracellular matrix mucopolysaccharide hyaluronan, has been a key component of many important studies on embryonic and tumour-induced lymphangiogenesis, and continues to be used for the detection and isolation of lymphatic endothelial cells.

Hence, LYVE-1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. Keywords: hyaluronic acid; endothelium, lymphatic; DNA, complementary; receptors, cell surface; recombinant fusion proteins.