脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的重要成分，对细菌的生存和致病性具有重要影响。 LPS位于细菌外膜的外层，在无荚膜菌株中直接暴露在细胞表面。

2023年7月25日 · Caspase-11 (Casp-11) is known to induce pyroptosis and defends against cytosol-invading bacterial pathogens, but its regulation remains poorly defined. Here, we identified extended synaptotagmin 1 (E-Syt1), an endoplasmic reticulum protein, as a key regulator of Casp-11 oligomerization and activation.

糖萼的降解能使 HMGB1 或细菌外膜囊泡 (OMVs) 更高效的向胞浆内转运脂多糖 (LPS)，使得 caspase-11 的活化显著增强。而肝素 (Hep) 或非抗凝活性肝素 (NAH) 恰能有效的抑制肝素酶的活性，从而阻止糖萼的降解(下图)。

2015年9月16日 · Lipopolysaccharide (LPS) is the bacterial pathogen-associated molecular pattern that promotes caspase-11 activation 7, 8. Cytoplasmic LPS can directly bind to and...

2021年4月20日 · Our comparative analysis in B. thailandensis infection and endotoxemia models uncovered differential cell-type-specific roles of caspase-11 in antibacterial protection versus lethal inflammation; caspase-11 sensing of LPS in LyzM + myeloid cells plays a more critical role in antibacterial host defense than in lethal endotoxemia. The role of ...

2014年10月9日 · Caspase-11 activation-induced pyroptosis, in response to cytoplasmic lipopolysaccharide (LPS), is critical for endotoxic shock in mice. The mechanism underlying cytosolic LPS sensing and the responsible pattern recognition receptor are unknown.

2014年8月6日 · Caspase-11 activation-induced pyroptosis, in response to cytoplasmic lipopolysaccharide (LPS), is critical for endotoxic shock in mice. The mechanism underlying cytosolic LPS sensing and the...

LPS #11 is a paw up cat that was initially released in a Pet Pairs pack alongside LPS #12, with a green vine/orange flower perch swing. It was also released in a Singles pack, carry case (alongside LPS #1 ), and spring basket (alongside LPS #6 , #3 , and #13 )

近年来，一种称为含半胱氨酸的天冬氨酸蛋白水解酶 11(cysteinyl aspartate specific proteinase，Caspase-11，Casp-11)的发现，使我们不得不重新思考和认识机体如何识别 LPS 并对其产生反应 ．

LPS Shorthair Cat #11 is orange with airbrushed white markings on the snout and paws, white inner ears, a dark orange nose, dark orange airbrushed markings on the face, and light green eyes. This pet was first released in 2005 as a Pet Pairs pack with Parakeet #012, and included a swinging perch...