2004年11月1日 · The LIM domain is a modular protein-binding interface that is found in a wide variety of eukaryotic proteins with diverse biological functions.

Dysfunctions of LIM domains induce pathological effects including muscle detachment, embryonic lethality, and oncogenesis. Acting as a protein-protein interaction motif, the LIM domain has a …

2023年5月8日 · The LIM domain is an evolutionarily conserved protein module that was discovered in the late 1980s in the transcription factors Lin-11, Isl-1 and Mec-3, from which the …

Unlike GATA type zinc fingers, LIM domains mediate protein-protein interactions rather than directly bind DNA. LIM domain containing proteins have functionally diverse cellular roles as …

The LIM (L in-11, I sl1, M EC-3) domain-containing proteins are involved in a myriad of cellular mechanosensitive pathways. Recent work has discovered that LIM domains bind to …

LIM domains are zinc fingers that coordinate two zinc ions and which mediate protein-protein interactions. They are found in arrays of 1–5 LIM domains in a wide variety of proteins inside …

1998年4月1日 · The LIM domain is a specialized double-zinc finger motif found in a variety of proteins, in association with domains of divergent functions or forming proteins composed …

First described 15 years ago as a cysteine-rich sequence that was common to a small group of homeodomain transcription factors, the LIM domain is now recognized as a tandem zinc-finger …

2000年3月1日 · Identified as a domain mediating protein–protein interactions, the LIM domain is a crucial protein structure for the biological functions of many LIM proteins, thus emphasizing …

2023年5月8日 · The LIM domain is an evolutionarily conserved protein module that was discovered in the late 1980s in the transcription factors Lin-11, Isl-1 and Mec-3, from which the …