LHX3 encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification.

2024年12月25日 · LHX3 (LIM Homeobox 3) is a Protein Coding gene. Diseases associated with LHX3 include Pituitary Hormone Deficiency, Combined, 3 and Non-Acquired Combined Pituitary Hormone Deficiency-Sensorineural Hearing Loss-Spine Abnormalities Syndrome .

LHX3 is a transcription factor that belongs to the LIM-type homeodomain protein family. It is involved in cell specification and proliferation during development and is expressed in the pituitary, spinal cord, and medulla.

The Lhx3 gene encodes two isoforms, LHX3a and LHX3b, that differ in their amino-terminal sequences. A novel LHX3 protein (M2-LHX3) is identified and it is determined that this molecule is generated by an internal translation initiation codon.

2024年3月5日 · LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma. Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma. A recessive mutation resulting in a disabling amino acid substitution (T194R) in the LHX3 homeodomain causes combined pituitary hormone deficiency.

LHX3, a LIM-homeodomain transcription factor, is broadly expressed in the developing pituitary, spinal cord, medulla, retina and inner ear, and plays essential roles during embryonic development. Mice with homozygous Lhx3 null mutation exhibit failure in the formation of pituitary gland and die peri …

LHX3 expression is much higher in the advanced-stage patients than the early-stage patients, and is sharply increased in metastasic patients. High LHX3 expression is associated with unfavorable overall survival, and is an independent prognostic factor of patients.

2002年7月26日 · Lhx3 is involved in the generation of two adjacent, but distinct, cell types for locomotion, motor neurons and V2 interneurons. Using in vivo function and protein interaction assays, we found that Lhx3 binds directly to the LIM cofactor NLI …

2024年6月17日 · LHX3 is an early stage and radiosensitivity prognostic biomarker in lung adenocarcinoma. Lin X, et al. Oncol Rep, 2017 Sep. PMID 28731174, Free PMC Article. Lhx3 is required to maintain cancer cell development of high-grade oligodendroglioma. Liu H, et al. Mol Cell Biochem, 2015 Jan. PMID 25399296.

LHX3 is a member of the LIM-homeodomain (LIM-HD) subfamily of transcription factor proteins that are characterized by a DNA-binding homeodomain in the middle of the protein and two amino terminal LIM domains (cysteine-rich structures important for protein–protein interactions) [2].