2024年12月25日 · LATS1 (Large Tumor Suppressor Kinase 1) is a Protein Coding gene. Diseases associated with LATS1 include Malignant Peritoneal Mesothelioma and Tetraploidy. Among its related pathways are Hippo-Merlin signaling dysregulation and DNA IR-double strand breaks and cellular response via ATM.

Large tumor suppressor kinase 1 (LATS1) is an enzyme that in humans is encoded by the LATS1 gene. [5] [6] [7] It has been associated with the Hippo signaling pathway, where it phosphorylates YAP and TAZ to inactivate their function. [8]

LATS1/2 激酶反过来磷酸化并抑制转录共激活因子 YAP 和 TAZ（Hippo 通路的两个主要下游效应分子）。 去磷酸后，YAP/TAZ 转运到胞核，并与 TEAD1-4 及其他转录因子发生相互作用，从而诱导促进细胞增殖并抑制凋亡的基因表达。

由该基因编码的蛋白质是一种推定的丝氨酸/苏氨酸激酶，定位于有丝分裂器并在早期有丝分裂中与细胞周期控制器 CDC2 激酶复合。 蛋白质以细胞周期依赖性方式磷酸化，后期磷酸化一直保 …

大肿瘤抑制激酶1（lats1）和lats2是近年来发现的具有抑制肿瘤发生、发展功能的激酶，二者高度同源，并且在功能上有所重叠。lats1和lats2蛋白被证实与多种恶性肿瘤的发生相关，包括软组织肉瘤、白血病、星形细胞瘤、乳腺癌、前列腺癌、肺癌、肝癌、食管癌等。

4 天之前 · LATS1 regulates the cellular distribution of ZBTB20 in chondrocytes. a Representative images of immunofluorescence staining of ZBTB20 in primary chondrocytes exposed to IL-1β at concentrations ...

2017年6月23日 · The Dbf2-related kinases LATS1 and LATS2 (LATS) have emerged as central regulators of cell fate, by modulating the functions of numerous oncogenic or tumor suppressive effectors, including the ...

Lats1 SUMOylation at K751 suppresses its kinase activity and subsequently attenuates its tumor-suppressor functions in HepG2 cells. High LATS1 expression is associated with Colorectal Tumorigenesis and Metastasis.

2021年5月25日 · In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases—the core enzymes in Hippo signaling. The substance prevents Yap phosphorylation and induces...

研究人员（以下简称Britschgi等）发现LATS（large tumour suppressor kinases）1和2是Hippo通路的一部分，其缺失促进了管腔表型并增加了祖细胞数量，而这些细胞中的大多数恰巧是人类乳腺癌的起源，就机制而言，Britschgi等确定了Hippo和雌激素受体-α（ERα）信号之间的直接相互作用，在LATS存在下，ERα被 泛素化 及降解。 LATS的缺失稳定了ERα和Hippo 效应子 YAP和TAZ，它们通过内在和旁分泌机制共同控制乳腺细胞的命运。 这一发现揭示了LATS在调节人 …