lat1 对癌细胞生长至关重要，因为 lat1 的药理学抑制和敲低/敲除可抑制癌细胞的增殖和异种移植肿瘤的生长。 LAT1 的抑制通过下调 mTORC1 信号通路和调动癌细胞中的一般氨基酸控制 (GAAC) 通路来抑制蛋白质合成。

Sep 30, 2021 · LAT（L-type amino transporters），即L型氨基酸转运体，主要功能为中性氨基酸包括必须氨基酸的转运，亚型按照时间发现顺序依次为LAT1、LAT2、LAT3、LAT4，其中LAT1的研究相对最多。

Mar 13, 2019 · LAT1 forms a heteromeric amino acid transporter complex with 4F2 cell-surface antigen heavy chain (4F2hc; also known as SLC3A2)—a type II membrane glycoprotein that is essential for the ...

Due to the significant up-regulation of LAT1 expression in several human tumors, LAT1 has been an attractive transporter for targeted delivery of amino acid-derived anticancer drugs and prodrugs as well as positron emission tomography (PET) probes for cancer diagnosis.

Feb 14, 2025 · LAT1 (SLC7A5) transports large neutral amino acids and plays pivotal roles in cancer proliferation, immune response and drug delivery. Despite recent advances in structural...

Dec 25, 2024 · (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into host cell and increasing L-leucine uptake-mediated mTORC1 signaling activation, thereby contributing to HCV-mediated pathogenesis.

Feb 1, 2022 · LAT1 regulates cell proliferation upstream of mTORC1. In addition to inhibiting mTORC1, LAT1 inhibitors activate the GAAC pathway to suppress translation initiation. LAT1 is induced to be expressed in response to lysoPC and angiogenic growth factors in vascular endothelial cells, contributing to arteriosclerosis and tumor angiogenesis ...

LAT1 (also known as SLC7A5), is defined as a heteromeric amino acid transporter (HAT) interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide to uptake not only large neutral amino acids, but also several pharmaceutical drugs to cells.

Jan 9, 2015 · lat1介导的氨基酸转运对于蛋白质的合成和细胞的 生长增殖等非常重要，有必要对LAT蛋白活性调节 因子进行深入研究；细胞水平上对癌变细胞和正常

大中性氨基酸转运蛋白 1（LAT1 或 SLC7A5）是一种不依赖钠和 pH 的转运蛋白，为细胞提供必需氨基酸（例如亮氨酸、苯丙氨酸）。 它在血脑屏障 (BBB) 中发挥着重要作用，促进甲状腺激素、药物（例如左旋多巴、加巴喷丁）和代谢物转运至大脑。 此外，其表达在各种类型的人类癌症中高度上调，这些癌症的特征是生长和增殖对氨基酸的强烈需求。 因此，LAT1被认为是癌症治疗的重要药物靶点。 随着大肠杆菌中精氨酸/胍丁胺逆向转运蛋白 (AdiC) 的结晶，建立了许多 LAT1 …