L-selectin, also known as CD62L, is a cell adhesion molecule found on the cell surface of leukocytes, and the blastocyst. It is coded for in the human by the SELL gene. L-selectin belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups containing a Sialyl LewisX (sLeX) determinant. [ 5 ]

2019年5月14日 · L-selectin (CD62L) is a type-I transmembrane glycoprotein and cell adhesion molecule that is expressed on most circulating leukocytes. Since its identification in 1983, L-selectin has been extensively characterized as a tethering/rolling receptor.

L-selectin is the smallest of the vascular selectins, expressed on all granulocytes and monocytes and on most lymphocytes, can be found in most leukocytes. P-selectin, the largest selectin, is stored in α-granules of platelets and in Weibel–Palade bodies of endothelial cells, and is translocated to the cell surface of activated endothelial ...

2023年7月19日 · L-selectin. L-selectin is a 74 to 100 kDa glycoprotein involved in lymphocyte homing and adhesion to endothelial cells in peripheral lymph nodes.

L-selectin is a cell adhesion molecule consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. It is expressed on most leukocytes and is involved in their rolling on inflamed vascular endothelium prior to …

L-selectin is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues.

L-selectin (CD62L) is expressed on most leukocytes. Its most important function is in lymphocyte homing to secondary lymphatic organs [297], but it also has an accessory function in inflammation [131, 298]. Like the other selectins, L-selectin can mediate leukocyte rolling, a blood flow-driven motion of leukocytes along the vessel wall.

2019年5月13日 · L-selectin shedding is a classic readout for neutrophil activation and/or “priming” (i.e., partial activation), which is concordant with an upregulation in CD11b expression (αMβ2 or Mac-1) .

The selectins are transmembrane, Ca2+-dependent lectins that mediate leucocyte rolling on vascular surfaces, the first adhesive step during inflammation and immune surveillance. Leucocytes express L-selectin, activated platelets express P-selectin, ...

L‐selectin is a cell adhesion molecule consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. It is expressed on most leukocytes and is involved in their rolling on ...

L-Selectin is a member of the selectin family of adhesion molecules that is expressed on all types of leukocytes. It functions as a homing receptor in naive lymphocytes, directing them to the peripheral lymph nodes.

This review focuses on the ligands for L-selectin that are found on vascular endothelium, leukocytes, carcinoma cells, and at various extravascular sites. The discovery of selectins and their ligands has validated the long-predicted hypothesis that carbohydrate-directed cell adhesion is relevant in eukaryotic systems.

L-selectin, which is found on leukocytes, was the first discovered, by virtue of an interesting phenomenon called lymphocyte homing, in which lymphocytes were removed from various peripheral lymph nodes, labeled, and then injected back into the animal.

2012年4月1日 · The leukocytic cell adhesion receptor l-selectin mediates the initial step of the adhesion cascade, the capture and rolling of leukocytes on endothelial cells. This event enables leukocytes to migrate out of the vasculature into surrounding tissues during inflammation and immune surveillance.

L-selectin is a calcium-dependent lectin-like receptor1,2 that is widely distributed on all leukocytes in the blood and belongs to the newly emerging selectin family of cell-cell adhesion proteins, which includes E-selectin and P-selectin3.

L-selectin expression on peripheral blood leucocytes in patients with SSc. The frequency of L-selectin-expressing leucocytes from patients with SSc was assessed (Figs 2 and 3).Although a subpopulation of CD4 + T cells, CD16 + NK cells, or CD14 + monocytes did not express L-selectin in both SSc patients and normal controls, the frequency of L-selectin + cells among …

These parts of the selectin molecules are responsible for their targeting to different compartments: P-selectin to secretory granules, E-selectin to the plasma membrane, and L-selectin to the tips of microfolds on leukocytes.

2002年2月1日 · This article reviews recent advances in the knowledge of the role of L-selectin, an adhesion molecule that is expressed on the surface of circulating leucocytes, in animal and human physiology and

L-selectin controls the capacity for naïve T cells to migrate to the lymph nodes (LN), whereas P- and E-selectin capture activated T cells on activated inflamed endothelium to initiate their migration into non-lymphoid tissues (Hobbs and Nolz 2017).

2021年2月8日 · L-selectin is a cell adhesion molecule abundantly expressed on circulating neutrophils. For over two decades, neutrophil L-selectin has been assigned the exclusive role of supporting tethering and rolling - the initial stages of the multi-step adhesion cascade.

2025年3月1日 · The selectin family (P-, E-, and L-selectin) has been implicated in the endothelial-mediated inflammation during IR, with P-selectin being involved in the initial interaction between leukocytes ...

The leukocytic cell adhesion receptor L-selectin mediates the initial step of the adhesion cascade, the capture and rolling of leukocytes on endothelial cells. This event enables leukocytes to migrate out of the vasculature into surrounding tissues during inflammation and …