The reduced KV1.5 expression is the common highlight of the human PAH implying its important role in PH pathogenesis. Downregulation of Kv channels activity, notably Kv1.5, induces membrane depolarization leading the calcium influx through Kv dependent calcium channels and an increase of cytosolic Ca +2 concentration

Because of its unique atrial specific expression, Kv1.5 is an ideal pharmacological target for AF treatment that may avoid the undesired proarrhythmic activities . Numerous Kv1.5 blockers have been in development, but to date, most of them have failed to reach clinical trials for various reasons [ 181 ].

The pore-forming alpha-subunit, Kv1.5, forms functional voltage-gated K(+) (Kv) channels in human pulmonary artery smooth muscle cells (PASMC) and plays an important role in regulating membrane potential, vascular tone, and PASMC proliferation and apoptosis.

2013年10月9日 · Kv1.5 currents contribute to the ultra-rapid activating K + current in the heart known as I kur, which plays a role in the repolarization of an action potential (Lesage et al., 1992). The conductance of the Kv1.5 channel is 8 pS, and the voltage required for activation is ~24 mV.

Existing data suggests that expression of Kv1.5 is evident in β-cells and peripheral insulin-sensitive tissues, including adipocytes and skeletal muscle, and Kv1.5 inhibition contributes to the glucose uptake in adipocytes and soleus muscle [59] and insulin release in β-cells [60].

Kv1.5, encoded by KCNA5, is a member of the Shaker superfamily of Kv channels. Kv1.5 channels are expressed in a number of cell types such as atrial myocytes (1, 2), smooth muscle cells (3, 4), and pancreatic beta cells .

2003年9月18日 · In this study, we reassessed the molecular components underlying one current, the ultrarapid delayed rectifier current in canine atrium [IKur (d)], by evaluating the mRNA, protein, immunofluorescence, and currents of the candidate channels.

2023年6月19日 · In particular, the rapidly activating voltage-gated K + channel Kv1.5, responsible for the ultrarapid delayed rectifier current I Kur that contributes significantly to atrial...

2024年12月25日 · Kv1.5/KCNA5 sub-subfamily. Domain: The amino terminus may be important in determining the rate of inactivation of the channel while the C-terminal PDZ-binding motif may play a role in modulation of channel activity and/or targeting of …

Biolistically introduced exogenous voltage-gated potassium channel, Kv1.5, is functional and, like endogenous Kv1.5, localizes to the intercalated disc, where it is expressed at the surface of that structure.