Jul 4, 2022 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for …

Jun 1, 2024 · Voltage-gated potassium channel 1.3 (Kv1.3) has emerged as a pivotal player in numerous biological processes and pathological conditions, sparking considerable interest as …

Therapeutic targeting K V 1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as multiple sclerosis, type I …

Jan 13, 2020 · Kv1.3 channel blockers have been found to alleviate disease symptoms in animal autoimmune diseases, chronic inflammatory diseases, and metabolic disease models without …

Sep 4, 2024 · Kv1.3 is a multifunctional potassium channel implicated in multiple pathologies, including cancer. However, how it is involved in disease progression is not fully clear. We …

Mar 1, 2017 · Electrophysiology studies have implicated the potassium ion (K +) channel Kv1.3 as having a critical role in the regulation of chronically activated effector memory T (T EM) cell …

Feb 6, 2021 · Since the discovery of the Kv1.3 voltage-gated K+ channel in human T cells in 1984, ion channels are considered crucial elements of the signal transduction machinery in the …

Introduction: Kv1.3 is the main voltage-gated potassium channel of leukocytes from both the innate and adaptive immune systems. Channel function is required for common processes …

Apr 7, 2021 · We show Kv1.3 channels regulate respiration through a non-conducting mechanism to generate reactive oxygen species which drive proliferation.

Jul 4, 2022 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for …

ShK and Kv1.3 blocking polypeptides as potential therapeutic agents for neuroinflammatory diseases. ShK and Kv1.3 toxins might be used to treat multiple sclerosis, and other …

Jul 22, 2022 · This study visualizes Kv1.3 pore dynamics, defines two distinct mechanisms to suppress Kv1.3 channel activity with exogenous inhibitors, and provides a framework to aid …

Sep 23, 2019 · Channel activation enables transportation of potassium ions down their electrochemical gradient. Kv1.3 channel is expressed in many cell types, both normal and …

Jul 10, 2020 · Here, we give a short overview of the main characteristics of Kv1.3 channels and then focus on recent advances in the use of Kv1.3 blockers in the treatment of hematological …

The voltage-dependent potassium channel Kv1.3 is a potential target for cancer therapies. This channel exhibits a complex repertoire of physiological functions such as proliferation, …

Since the discovery of the Kv1.3 voltage-gated K + channel in human T cells in 1984, ion channels are considered crucial elements of the signal transduction machinery in the immune …

Apr 19, 2022 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for …

Nov 1, 2020 · In this study, treatment of ureteral unilateral obstruction rats using the Kv1.3-blocking peptide MgTx reduced the size of the kidney cortical interstitium and decreased the …

Results: Kv1.3 in the nucleus regulates nuclear membrane potential and activates transcription factors. Conclusion: Kv1.3 is a functional channel at the nucleus. Significance: This study …

Jun 1, 2003 · Activated myelin-reactive T cells from patients with MS exhibited the Kv1.3 high IKCa1 low T EM phenotype, suggesting that they have undergone repeated stimulation during …