2018年10月24日 · Kv1.2 is a prominent voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. We explored multi-protein complexes...

Potassium Channel Kv1.2 is a type of voltage-gated potassium channel that is located in the juxatanodal domain of axons. It primarily produces a sustained outward potassium current and influences the action potential threshold for subsequent action potentials. AI generated definition based on: Neuroscience, 2009

2025年2月13日 · We present near-atomic-resolution cryoEM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium-bound states at 3.2 Å, 2.5 Å, 3.2 Å, and 2.9 Å.

2005年8月5日 · We investigated the mechanism by which these channels sense cell membrane voltage by determining the x-ray crystal structure of a mammalian Shaker family potassium ion (K +) channel.

In this study, by applying a novel normal-mode-based X-ray crystallographic refinement method to the original diffraction data and structural model, we established the structure of full-length Kv1.2 in its native form. This structure offers mechanistic insights into voltage sensing.

Kv1.1 and Kv1.2 knockout mice both have seizures beginning early in development; however, each express a different seizure type (pathway), although the channels are from the same subfamily and are abundantly coexpressed.

2024年12月18日 · Fluorescence, a high level of membrane expression of K-Kv1.2, and a high affinity of the HgTx-G ligand for the Kv1.2 channel significantly facilitate the use of K-Kv1.2, HgTx-G, and laser scanning fluorescence microscopy to qualitatively discriminate and quantitatively study peptide blockers of Kv1.2 using a previously developed methodological ...

2024年12月18日 · The results indicated a correlation between KCNA2 expression and patient survival. The data also demonstrated that KCNA2/Kv1.2 is a direct target of EWS::FLI1, and identified the molecular mechanisms by which this chimeric protein regulates KCNA2 gene expression at the transcriptional level.

Two epilepsy-associated variants in KCNA2 (KV 1.2) at position H310 oppositely affect channel functional expression. An epilepsy-associated KV1.2 charge-transfer-center mutation impairs KV1.2 and KV1.4 trafficking.

Voltage-gated potassium Kv1.2 channels play pivotal role in maintaining of resting membrane potential and, consequently, regulation of cellular excitability of neurons. Endogenously generated electric field (EF) have been proven as an important regulator for cell migration and tissue repair.