
KMT2D - Wikipedia
Histone-lysine N-methyltransferase 2D (KMT2D), also known as MLL4 and sometimes MLL2 in humans and Mll4 in mice, is a major mammalian histone H3 lysine 4 (H3K4) mono …
KMT2D Gene - GeneCards | KMT2D Protein | KMT2D Antibody
2024年12月25日 · KMT2D (Lysine Methyltransferase 2D) is a Protein Coding gene. Diseases associated with KMT2D include Kabuki Syndrome 1 and Branchial Arch Abnormalities, …
KMT2D gene - MedlinePlus
The KMT2D gene, also known as MLL2, provides instructions for making an enzyme called lysine-specific methyltransferase 2D that is found in many organs and tissues of the body. Lysine …
KMT2D deficiency drives lung squamous cell carcinoma and ...
2023年1月9日 · KMT2D is one of the most frequently mutated genes in LUSC (>20%), and yet its role in LUSC oncogenesis remains unknown. Here, we identify KMT2D as a key regulator of …
Histone H3 lysine 4 methyltransferase KMT2D - PMC
KMT2D is a major mammalian H3K4 mono-methyltransferase and co-localizes with lineage determining transcription factors on transcriptional enhancers. It is required for the binding of …
KMT2D lysine methyltransferase 2D [ (human)] - National Center …
KMT2D represents a recurrently mutated gene with potential implication for pheochromocytoma development. Identify MLL4 as a major mammalian H3K4 mono- and di-methyltransferase …
Cancer-epigenetic function of the histone methyltransferase KMT2D …
Recent studies have demonstrated how KMT2D loss induces abnormal epigenomic reprograming and rewires molecular pathways during tumorigenesis. These findings also have clinical and …
KMT2D lysine methyltransferase 2D [ Homo sapiens (human) ]
2024年12月10日 · Title: The histone methyltransferase KMT2D maintains cellular glucocorticoid responsiveness by shielding the glucocorticoid receptor from degradation. Histone …
Histone methyltransferase KMT2D sustains prostate carcinogenesis …
2017年12月22日 · Our present study revealed that KMT2D epigenetically activates PI3K/Akt pathway and EMT by targeting LIFR and KLF4 and thus serves as a putative epigenetic-based …
Entry - *602113 - LYSINE-SPECIFIC METHYLTRANSFERASE 2D; KMT2D - OMIM
KMT2D, a histone H3 lysine-4 methyltransferase, is required for FOXA1 (602294), PBX1 (176310), and ER recruitment and activation. AKT binds and phosphorylates KMT2D, …