Dec 25, 2024 · KLRD1 (Killer Cell Lectin Like Receptor D1) is a Protein Coding gene. Diseases associated with KLRD1 include Nk Cell Deficiency and Chronic Nk-Cell Lymphocytosis. Among its related pathways are DAP12 interactions and Innate Immune System.

KLRD1, also known as CD94, plays a critical role in immune surveillance by forming a receptor complex with NKG2 molecules 8-10. Many factors influence the expression of KLRD1 molecules, including cytokines such as IL-12 and IFN-gamma, viral infections, and tumor factors.

KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene.

May 5, 2021 · Antibodies targeting PD1 or PD-L1 have achieved substantial overall survival improvements in advanced non-small cell lung cancer (NSCLC). The 5-year survival rate could be prolonged from less than...

KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene.

Jan 1, 2025 · Background: Killer Cell Lectin Like Receptor D1 (KLRD1) plays a crucial role in antitumor immunity. However, its expression patterns across various cancers, its relationship with patient prognosis, and its potential as an immunotherapy target remain inadequately understood.

KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene.

KLRD1 forms a dimer with KLRC1 (NKG2A) [54], binds to HLA-E and inhibits cytotoxicity, whereas with KLRD1 (NKG2C) or KLRK1 can deliver a stimulatory function when expressed on CD8 T cells [55]. By contrast, NCR1, and CD244 are activation receptors.

Feb 9, 2024 · Additionally, we also identified other immune checkpoints of NKs in our system, such as KLRG1, KLRD1, KLRK1, KLRC2, and KLRC3, which may also get involved in the NKs-mediated immune...

KLRD1 (CD94) is an antigen preferentially expressed on NK cells and is classified as a type II membrane protein because it has an external C terminus. Several transcript variants encoding different isoforms have been found for this gene.