Dec 25, 2024 · KDM4C (Lysine Demethylase 4C) is a Protein Coding gene. Diseases associated with KDM4C include Hematologic Cancer and Squamous Cell Carcinoma. Among its related pathways are RNA Polymerase I Promoter Opening and Signaling by Rho GTPases. Gene Ontology (GO) annotations related to this gene include enzyme binding and dioxygenase activity.

Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene. [5][6][7] This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains.

编码的蛋白质是一种三甲基化特异性去甲基化酶，可将特定的三甲基化组蛋白残基转化为二甲基化形式。 这种酶促作用调节基因表达和染色体分离。 在肿瘤细胞中可能会发现染色体畸变和该基因表达的变化。 可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 1 月] This gene is a member of the Jumonji domain 2 (JMJD2) family. The encoded protein is a trimethylation-specific demethylase, and converts specific trimethylated histone residues to the dimethylated form.

Feb 9, 2021 · KDM4C（组蛋白赖氨酸脱甲基酶4C，也称为JMJD2C/GASC1）是JmjC蛋白家族的成员之一，其编码与H3K9me3/2和H3K36me3/2相关的组蛋白去甲基化酶，且已证实该基因与肿瘤的恶性转化相关。

Jan 18, 2021 · KDM4C is a histone H3K9 demethylase that contributes to epigenetic regulation of both oncogene and tumor suppressor genes and is often overexpressed in human...

Feb 8, 2021 · Here, we show that lysine-specific demethylase 4C (KDM4C) is overexpressed and correlated with poor prognosis in lung cancer patients. We provide evidence that genetical or pharmacological...

Apr 28, 2023 · Here, we find that KDM4C protein expression is increased in HCC and promotes HCC cell growth, proliferation and migration. Furthermore, we provide evidence that depletion of KDM4C leads to a...

Mechanistically, KDM4C inhibition increased the binding of H3K36me3 to the CXCL10 promoter region, thus inducing CXCL10 transcription and enhancing the CD8 + T cell mediated antitumor immune response. More importantly, among the tested regimens, the triple therapy achieved the best therapeutic efficacy with tolerable toxicity in lung cancer.

Oct 1, 2016 · KDM4C, also known as JMJD2C/GASC1, is a member of the KDM4 subgroup of JmjC domain-containing proteins which catalyzes the demethylation of tri- and dimethylated lysine 9 and lysine 36 on histone H3. KDM4C was first identified as an oncogene that is amplified in esophageal cancer cell line, KYSE-150 [13].

Title: KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations. The histone demethylase JMJD2C constitutes a novel NFE2 target gene that is required for the survival of JAK2[V617F] mutated cells.