2024年12月25日 · KDM2B (Lysine Demethylase 2B) is a Protein Coding gene. Diseases associated with KDM2B include Hematologic Cancer and Large B-Cell Lymphoma. Among its …

In this review, we summarize the structure and biological function of KDM2B, and highlight its key findings in cancer. KDM2B, also known as JHDM1B/FBXL10/NDY1, is a conserved and …

2017年6月29日 · We interrogated 48 genes in DNA and histone modification pathways and identified KDM2B, an H3K36-specific demethylase, as a novel regulator of TRAIL response. …

2023年10月14日 · Kdm2b∆CxxC mice display prominent defects in spatial memory, motor learning and fear conditioning, resembling patients with KDM2B mutations. The migration and …

2025年2月9日 · KDM2B, an H3K36 histone demethylase implicated in bypass of cellular senescence and somatic cell reprogramming, is markedly overexpressed in PDAC, with levels …

Here, we show that KDM2B, also known as FBXL10 and a member of the Jumonji C family of proteins known for its histone H3K36 demethylase activity, is a di- and trimethyl H3K79 …

2024年5月22日 · KDM2B is a JmjC domain lysine demethylase, which promotes cell immortalization, stem cell self-renewal and tumorigenesis. Here we employed a multi-omics …

We present evidence, including a shared epigenetic signature, to support a pathogenic classification of 15 KDM2B variants and identify the CxxC domain as a mutational hotspot. …

2013年3月17日 · Here, we show that the H3K36-specific histone demethylase Kdm2b is highly expressed in mESCs and regulated by the pluripotent factors Oct4 and Sox2 directly. …

Gao et al., 2022 demonstrated that Kdm2b played a critical role in maintaining neural stem cells (NSCs) in the mouse brain, and that heterozygous adult Kdm2b mutant mice displayed both …