KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector and effector memory CD8+ T and NK cells. Its ligands are E-cadherin and N-cadherin with similar affinities, [10] respective markers of epithelial and mesenchymal cells. [11]

2024年12月25日 · KLRG1 (Killer Cell Lectin Like Receptor G1) is a Protein Coding gene. Diseases associated with KLRG1 include Mastocytosis and Thyroid Dyshormonogenesis 3. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

2024年6月19日 · Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor expressed predominantly in NK and T-cell subsets that downregulates the activation and proliferation of immune cells and participates in cell-mediated immune responses.

The co-inhibitory receptor killer-cell lectin like receptor G1 (KLRG1) is expressed on NK cells and antigen-experienced T cells and has been postulated to be a marker of senescence. Whilst KLRG1 has frequently been used as a marker of cellular ...

2018年4月17日 · Our work demonstrates that developmental plasticity of KLRG1 + effector CD8 + T cells is important in promoting functionally versatile memory cells and long-term protective immunity.

2024年6月28日 · KLRG1 + CD8 T cells persist for months after clearance of acute infections and maintain high levels of effector molecules, contributing protective immunity against systemic

Killer cell lectin-like receptor G1 (KLRG1) is an immune checkpoint receptor encoded by the KLRG1 gene. It is an inhibitory lectin-like type II transmembrane receptor containing a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). 1 KLRG1 is primarily composed of a homodimeric molecule consisting of two 30–38 kDa N ...