KLF9 - Wikipedia
A Klf9 deficiency suppresses bleomycin-induced fibrosis in the lungs of mice. By introducing bleomycin to lung tissue, the tissue will produce ROS and develop fibrotic lung tissue to combat the damage done by the bleomycin.
摘 要：KLF9是锌指蛋白Krüppel样转录因子(Krüppel-like factors, KLFs)家族的重要成员，通过C 端的3 个 C2H2 锌指蛋白结构，结合到靶基因启动子区富含GC 的区域，调节靶基因的转录，从而参与调节细胞增殖、
KLF9 Gene - GeneCards | KLF9 Protein | KLF9 Antibody
Dec 25, 2024 · KLF9 (KLF Transcription Factor 9) is a Protein Coding gene. Diseases associated with KLF9 include Familial Partial Lipodystrophy and Otosclerosis. Among its related pathways are Familial partial lipodystrophy and Exercise-induced circadian regulation.
Klf9 is essential for cardiac mitochondrial homeostasis
Nov 8, 2024 · Here we show that cardiac Krüppel-like factor 9 (Klf9) is dysregulated in human and rodent cardiomyopathy. Both global and cardiac-specific Klf9-deficient mice displayed hypertrophic...
宋伟宏院士团队发现KLF9调控IFITM3表达参与Aβ产生-老年研究院…
Feb 17, 2025 · 本研究首次揭示了KLF9作为AD病理风险因子的重要作用，为深入解析Aβ生成的分子调控机制提供了新的理论依据，同时也为AD的靶向治疗策略提供了潜在的干预靶点。 我校宋伟宏院士是本研究的通讯作者，老年研究院副院长吴伊丽教授是本研究的共同通讯作者。 宋伟宏院士团队的博士研究生冯艺佳、硕士研究生周倩以及博士研究生胡波浪完成主要研究工作，为文章的共同第一作者。 1. Feng Y, Zhou Q,...
Krüppel-like factor KLF9 regulates PPAR - Nature
Aug 20, 2010 · Using promoter deletion and mutation analysis, we identified two KLF9-binding sites within the 0.6-kb region of the PPARγ2 proximal promoter, indicating that KLF9 interacts with the PPARγ2...
转录调节因子KLF9的研究进展
As a member of the Krüppel-like factors (KLFs) transcription factor family, KLF9 regulates the transcriptions of target genes by 3 C2H2 zinc finger motifs, binding to the GC rich region of the target promoters. KLF9 plays important roles in a variety of biological and cellular processes, including cell proliferation, differentiation, apoptosis ...
KLF9 KLF transcription factor 9 [ (human)] - National Center for ...
Feb 8, 2025 · KLF9 could down-regulate MMP9 expression to inhibit breast cancer metastasis. KLF9 status was associated with differentiation and vascular invasion expression and was found to be a valuable prognostic factor for patients with pancreatic ductal adenocarcinoma
KLF 转录因子 9（KLF9）基因 | MCE - MCE-生物活性分子大师
该基因编码的蛋白质是一种转录因子，可与位于启动子中的 GC 盒元件结合。 编码的蛋白质与单个 GC 盒的结合会抑制 mRNA 表达，而与串联重复的 GC 盒元件结合会激活转录。 [RefSeq 提供，2008 年 7 月] The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter.
转录调节因子KLF9的研究进展-【维普期刊官网】- 中文期刊服务平台
摘要 KLF9是锌指蛋白Krüppel样转录因子(Krüppel-like factors,KLFs)家族的重要成员,通过C端的3个C2H2锌指蛋白结构,结合到靶基因启动子区富含GC的区域,调节靶基因的转录...