2024年12月25日 · KLF6 (KLF Transcription Factor 6) is a Protein Coding gene. Diseases associated with KLF6 include Gastric Cancer and Prostate Cancer. Among its related pathways are Aryl hydrocarbon receptor pathway and Adipogenesis. …

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene. [5] It is a tumor suppressor gene. [6] This gene encodes a nuclear protein that has three zinc fingers at the end of its C-terminal domain, a serine/threonine-rich central region, and an acidic domain lying within the N-terminal region.

2017年8月14日 · Krüppel-like factor 6 (KLF6) is a ubiquitously expressed zinc finger transcription factor, which contributes to cell proliferation, differentiation, cell death and signal transduction 1.

Dysregulation of KLF functions have been shown to disrupt cellular homeostasis and contribute to disease development. KLF6 is a relevant example; a range of functional and expression assays suggested that the dysregulation of KLF6 contributes to the onset of cancer, inflammation-associated diseases as well as cardiovascular diseases.

2001年12月21日 · Kruppel-like factor 6 (KLF6) is a zinc finger transcription factor of unknown function. Here, we show that the KLF6 gene is mutated in a subset of human prostate cancer. Loss-of-heterozygosity analysis revealed that one KLF6 allele is deleted in 77% (17 of 22) of primary prostate tumors.

2025年1月18日 · Title: KLF6 activates Sp1-mediated prolidase transcription during TGF-β(1) signaling. Machine learning-based classification of deubiquitinase USP26 and its cell proliferation inhibition through stabilizing KLF6 in cervical cancer.

KLF6 Silencing Impairs Oxidative and Oncogene-Induced Cellular Senescence. To verify whether KLF6 is involved in cellular senescence induction, we down-regulated endogenous KLF6 levels by stable expression of a KLF6 shRNA in NIH3T3 fibroblasts (shKLF6).

3 天之前 · FOSL2 and KLF6 emerged as pivotal TFs potentially modulating DEGs associated with H3K23su DERs and were found to be essential for sustaining 5-FU resistance. Notably, we discovered that FOSL2 and ...

2023年6月1日 · This review focuses on four widely investigated KLF members, KLF2, KLF4, KLF6, and KLF7, describing their molecular characteristics, physiological functions, regulatory factors, roles in cancer, and treatment.

KLF6 directly binds and represses PTTG1 expression during induction of myeloid differentiation. This identifies KLF6 as a novel mediator of t(8;21) target gene regulation, providing a new mechanism for RUNX1-ETO transcriptional control. KLF6 is a novel regulator of hepatic glucose and lipid metabolism in fatty liver.