Dec 25, 2024 · KLF5 (KLF Transcription Factor 5) is a Protein Coding gene. Diseases associated with KLF5 include Cardiomyopathy, Dilated, 1Ff and Cardiomyopathy, Familial Hypertrophic, 25 . Among its related pathways are Transcriptional regulation of white adipocyte differentiation and White fat cell differentiation .

Krüppel-like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration.

KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a number of gene promoters and regulating their transcription. KLF5 is expressed during development and, in adults, with higher levels in proliferating epithelial cells.

May 2, 2023 · Here, we define an incoherent feed-forward loop in non-transformed human squamous epithelial cells involving p53 and the zinc-finger transcription factor KLF5 that dictates responses to...

Oct 27, 2021 · KLF5 plays a crucial role in stem cells of colorectum in cooperation with Lgr5 gene. In this study, we aimed to explicate a regulatory mechanism of the KLF5 gene product from a view of...

Apr 22, 2024 · KLF5 regulates actin remodeling and lamellipodia formation to promote the metastasis of NPC cells in vitro and in vivo. Mechanistically, KLF5 preferentially occupies distal enhancer regions...

Feb 8, 2025 · KLF5 regulates actin remodeling to enhance the metastasis of nasopharyngeal carcinoma. Abrogation of KLF5 sensitizes BRCA1-proficient pancreatic cancer to PARP inhibition. KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43.

Nov 27, 2024 · Title: KLF5 promotes the ossification process of ligamentum flavum by transcriptionally activating CX43. Ubiquitin specific peptidase 38 epigenetically regulates KLF transcription factor 5 to augment malignant progression of lung adenocarcinoma.

Jun 10, 2019 · The transcription factor KLF5 (Krüpple-like factor 5) is highly expressed in basal-like breast cancer (BLBC), which promotes cell proliferation, survival, migration and stemness, serving as a potential therapeutic target.

Krüppel‐like factor 5 (KLF5) is a member of the KLF family. Recent studies have suggested that KLF5 regulates the expression of a large number of new target genes and participates in diverse cellular functions, such as stemness, proliferation, apoptosis, autophagy, and migration.