Krüppel-like Factor 2 (KLF2), also known as lung Krüppel-like Factor (LKLF), is a protein that in humans is encoded by the KLF2 gene on chromosome 19.

KLF2 knockout (KO) T cells aberrantly acquired distinct features of exhaustion during acute LCMV infection. This included impaired effector and memory differentiation and function during both primary and secondary viral challenge.

Jan 2, 2025 · KLF2 was required to suppress the exhaustion-promoting TF TOX and to enable the TF TBET to drive effector differentiation. KLF2 was also necessary to maintain a polyfunctional tumor-specific progenitor state.

Dec 25, 2024 · Complete information for KLF2 gene (Protein Coding), KLF Transcription Factor 2, including: function, proteins, disorders, pathways, orthologs, and expression.

Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing.

This study provides the first evidence that transcription factor KLF2 serves as a negative regulator of cardiac hypertrophy. Our findings highlight the therapeutic potential of enhancing KLF2 expression, particularly through simvastatin administration, as a promising strategy in the treatment of car …

Feb 9, 2025 · KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling. KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma.

Feb 1, 2025 · Targeting KLF2 may represent a novel therapeutic approach against cardiac hypertrophy. Given the inhibitory effect of KLF2 on cardiac hypertrophy, it is imperative to explore the clinical benefits of KLF2 activators including simvastatin for …

Jun 5, 2014 · Klf2 is critical for ground state pluripotency. Klf2 is negatively regulated by Mek/Erk signaling at the posttranslational level. Erk2 directly interacts with and phosphorylates Klf2. Overexpression of Klf2 can replace Mek inhibition during ground state pluripotency. The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum.

Oct 13, 2021 · Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing.