KLF2 knockout (KO) T cells aberrantly acquired distinct features of exhaustion during acute LCMV infection. This included impaired effector and memory differentiation and function during both primary and secondary viral challenge.

2024年12月25日 · Complete information for KLF2 gene (Protein Coding), KLF Transcription Factor 2, including: function, proteins, disorders, pathways, orthologs, and expression.

2025年1月2日 · KLF2 was required to suppress the exhaustion-promoting TF TOX and to enable the TF TBET to drive effector differentiation. KLF2 was also necessary to maintain a polyfunctional tumor-specific progenitor state.

2021年10月13日 · Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing.

2025年2月9日 · KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling. KLF2 inhibits cancer cell migration and invasion by regulating ferroptosis through GPX4 in clear cell renal cell carcinoma.

KLF2 is a member of the Krüppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells.

2014年6月5日 · Klf2 is critical for ground state pluripotency. Klf2 is negatively regulated by Mek/Erk signaling at the posttranslational level. Erk2 directly interacts with and phosphorylates Klf2. Overexpression of Klf2 can replace Mek inhibition during ground state pluripotency. The maintenance of mouse embryonic stem cells (mESCs) requires LIF and serum.

2024年5月1日 · These insights underscore the differential transcriptional and epigenetic regulation of Klf2, presenting a novel mechanism that influences the cell fate decision of CD8 T cells during chronic infections.

2025年2月1日 · Targeting KLF2 may represent a novel therapeutic approach against cardiac hypertrophy. Given the inhibitory effect of KLF2 on cardiac hypertrophy, it is imperative to explore the clinical benefits of KLF2 activators including simvastatin for …

2011年2月7日 · KLF2 is a key molecular switch in vascular homeostasis, involved in regulating endothelial phenotype and transcription programs. It also plays important roles in vasculogenesis, angiogenesis, and heart valve formation. Recent data suggest that KLF2 mediates the pleiotropic effects of statins.