Dec 25, 2024 · KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) is a Protein Coding gene. Diseases associated with KIR3DL1 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation.

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene. [5] [6] [7] Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.

Mar 4, 2025 · Title: Expression profile of KIR3DS1/KIR3DL1 receptors in association with immunological responses in TB, HIV and HIV/TB infected patients. HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19.

Oct 23, 2011 · Here we describe the structure of a human KIR3DL1 receptor bound to HLA-B*5701 complexed with a self-peptide. KIR3DL1 clamped around the carboxy-terminal end of the HLA-B*5701 antigen-binding...

KIR 基因簇的基因含量因单倍型而异，尽管在所有单倍型 (KIR3DL3、KIR3DP1、KIR3DL4、KIR3DL2) 中都发现了几个“框架”基因。 KIR 蛋白根据细胞外免疫球蛋白结构域 (2D 或 3D) 的数量以及它们是否具有长 (L) 或短 (S) 细胞质结构域进行分类。 具有长细胞质结构域的 KIR 蛋白通过基于免疫酪氨酸的抑制基序 (ITIM) 在配体结合后转导抑制信号，而具有短细胞质结构域的 KIR 蛋白缺乏 ITIM 基序，而是与 TYRO 蛋白酪氨酸激酶结合蛋白结合以转导激活信号。 几种 KIR 蛋白 …

Aug 25, 2021 · In this study, we focus on differential NK cell activity modulation through KIR3DL1 allotypes. KIR3DL1 expression levels varied according to their alleles. The combination of KIR3DL1 expression level and HLA-Bw4 motifs defined NK cell activity in response to the CML-derived K562 cell line, and Ab-mediated KIR3DL1 blocking reversed this activity.

Nov 23, 2023 · HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19. Killer cell immunoglobulin-like receptor three domains long cytoplasmic tail 1 gene *007 may modulate disease progression of human immunodeficiency virus-1 infection in the Japanese population.

KIR3DL1 is a highly polymorphic receptor that binds to groups of HLAA and HLA-B allotypes that express the Bw4 epitope. The variation in KIR3DL1 allotypes manifests at a number of levels. Most dramatically, a common allelic variant encodes an activating rather than an inhibitory receptor (KIR3DS1).

studies indicate that KIR3DL1 expression may negatively regulate Treg function and suggest a previously undescribed target for improving immune tolerance for potential treatment of autoimmune diseases like IDDM; cloned Kir cDNAs from multiple strains of mice.

KIR3DL1 encodes a deduced 444-amino acid type I transmembrane protein. Sequence analysis showed that KIR3DL1 has a 21-amino acid signal peptide, an extracellular region containing three C2-type Ig-like domains with 3 potential N-linked glycosylation sites, a 20-amino acid hydrophobic transmembrane region, and an 84-amino acid cytoplasmic domain.