Dec 25, 2024 · JUNB (JunB Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with JUNB include Small Cell Carcinoma and Anaplastic Large Cell Lymphoma. Among its related pathways are IL-1 Family Signaling Pathways and Gene expression (Transcription).

Transcription factor jun-B is a protein that, in humans, is encoded by the JUNB gene. [5][6] Transcription factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It binds to the DNA sequence 5'-TGA [CG]TCA-3'. JUNB has been shown to interact with. SMAD3. [8]

Jun B proto-oncogene (JunB) is a crucial member of dimeric activator protein-1 (AP-1) complex, which plays a significant role in various physiological processes, such as placental formation, cardiovascular development, myelopoiesis, angiogenesis, ...

Dec 9, 2022 · Our results reveal novel functions for JUNB in cell proliferation and tumor aggressiveness through regulation of cyclin E1 and TGF-β2 expression, which might be exploited for cancer prognosis and therapy.

Sep 4, 2023 · This review summarizes the physiological function of JunB, its immune regulatory function, and its contribution to tumorigenesis, especially focusing on its regulatory mechanisms within tumor-associated immune processes.

Dec 17, 2018 · JunB promotes expression of Treg effector molecules, such as ICOS and CTLA4, in BATF-dependent and BATF-independent manners, and is also required for homeostasis and suppressive functions of...

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Jul 8, 2019 · The AP-1 transcription factor JunB plays crucial roles in multiple biological processes, including placental formation and bone homeostasis.

Jan 1, 2015 · Our analysis predicted a novel relationship between the AP-1 family transcription factor Junb and the gene Il1b, encoding the pyrogen IL-1β, which macrophages express upon activation by inflammatory stimuli.

JunB is a member of the AP-1 (activator protein-1) family of dimeric transcription factors. It exerts a dual action on the cell cycle. It is best known as a cell proliferation inhibitor, a senescence inducer and a tumour suppressor.