2013年5月15日 · KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein family consists of three ~130-kDa proteins (KDM4A-C) and KDM4D/JMJD2D, which is half the size, lacks the double PHD and Tudor domains that are epigenome readers and present in the other KDM4 proteins, and has a …

2022年9月1日 · JMJD2 is one of the largest JMJD subfamilies and is comprised of JMJD2A-D proteins, also referred to as KDM4A-D. JMJD2 family members take active parts in multiple physiological processes ...

2011年5月9日 · JMJD2 proteins are lysine trimethyl–specific histone demethylases that catalyze the demethylation of trimethylated H3K9 (H3K9me3) and H3K36 (H3K36me3). Genome-wide studies show that H3K9me3 is enriched in heterochromatin ( 15 ), which predicts that the H3K9me3 demethylase activities of JMJD2 proteins may act as transcriptional activators.

2021年1月13日 · Histone demethylase JMJD2 (also known as KDM4) family proteins have been previously shown to support self-renewal and differentiation of stem cells. However, their roles in the context of the...

KDM4/JMJD2 proteins are demethylases that target histone H3 on lysines 9 and 36 and histone H1.4 on lysine 26. This protein family consists of three ~130 kDa proteins (KDM4A–C) and KDM4D/JMJD2D, which is half the size, lacks the double PHD and Tudor domains that are epigenome readers and present in the other KDM4 proteins, and has a different ...

Here we report studies on the inhibition of the JMJD2 subfamily of histone demethylases, employing binding analyses by nondenaturing mass spectrometry (MS), dynamic combinatorial chemistry coupled to MS, turnover assays, and crystallography.

2006年5月5日 · We show the JmjC domain-containing protein JMJD2A reversed trimethylated H3-K9/K36 to di- but not mono- or unmethylated products. Overexpression of JMJD2A but not a catalytically inactive mutant reduced H3-K9/K36 trimethylation levels in cultured cells.

2019年10月3日 · KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations. Here, we investigate the long-term effects of depleting KDM4 activity on normal hematopoiesis to probe potential si …

JMJD2B, also known as KDM4B, is a JmjC domain-containing histone demethylase belonged to the JMJD2 protein family. JMJD2B mainly targets the trimethyl of lysine 9 of histone H3 (H3K9me3) to catalyze its demethylation reaction.

2019年10月3日 · KDM4 demethylases are required for sustained expression of genes important for survival of HSCs. KDM4/JMJD2 are H3K9- and H3K36-specific demethylases, which are considered promising therapeutic targets for the treatment of acute myeloid leukemia (AML) harboring MLL translocations.