Feb 1, 2021 · The c-Jun N-terminal protein kinases (JNKs) JNK1 and JNK2 can act as either tumor suppressors or pro-oncogenic kinases in human cancers.

Sep 10, 2004 · JNK2 is preferentially bound to c-Jun in unstimulated cells, thereby contributing to c-Jun degradation. In contrast, JNK1 becomes the major c-Jun interacting kinase after cell stimulation. These data provide mechanistic insights into …

Sep 15, 2006 · We show that JNK2 is a positive regulator of cJun expression and cellular proliferation. This conclusion contrasts with the results of previous studies of JNK2 based on the analysis of Jnk2 gene disruption. Competition between JNK isoforms accounts for the misleading phenotype of Jnk2−/− cells.

Feb 19, 2021 · We have identified a novel JNK2-induced activation of SERCA2. The dual action of JNK2 in CaMKII-dependent arrhythmic SR Ca²⁺ leak and a CaMKII-independent uptake exacerbates atrial arrhythmogenicity, while helping to maintain normal levels of Ca²⁺ transients and heart function. …

JNK1 and JNK2 are ubiquitously expressed in most tissues, whereas JNK3 expression is predominantly in brain, and, to a lesser extent, in the heart and testis 2. JNK signalling plays important functions in neurodegenerative diseases, inflammation, and cancer progression.

JNK1 and JNK2 have broad tissue distribution and play a potential role in insulin resistance, inflammation and cell signaling. JNK3 is predominantly found in the CNS neurons, making it an attractive target for neurodegenerative disorders.

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho、cdc42）的小分子 GTP 酶传递到这个级联。 和其他 MAPK 一样，膜近端激酶是一个 MAPKKK（通常为 MEKK1–4），或是混合性谱系激酶（MLK）中一员，能磷酸化并激活 MKK4 (SEK) 或 …

Oct 7, 2024 · JNK signaling, an integral component of the Mitogen-Activated Protein Kinase (MAPK) pathways, plays crucial roles in various cellular processes. Understanding this pathway is essential due to its involvement in critical functions like apoptosis and immunity.

May 2, 2018 · JNK1/2 phosphorylation paralleled a marked reduction in MAP kinase phosphatase 1 (JNK dephosphorylator) expression in patients’ lungs. Association of JNK1/2 activation with vascular modification was confirmed in the calf model of severe hypoxia-induced PH.

Aug 31, 2011 · JNK2 activation by onset of laminar shear activates inflammatory signaling but also promotes the adaptive morphological response that downregulates inflammation. Only under disturbed flow where cells cannot adapt does JNK lead to sustained inflammatory signaling.