The c-Jun N-terminal kinases consist of ten isoforms derived from three genes: JNK1 (four isoforms), JNK2 (four isoforms) and JNK3 (two isoforms). [2] Each gene is expressed as either 46 kDa or 55 kDa protein kinases, depending upon how the 3' coding region of the corresponding mRNA is processed.

JNK，（c-Jun 氨基末端 激酶，c-Jun N-terminal kinase）又被称为应激活化 蛋白激酶 (stress-activated protein kinase, SAPK)，是 哺乳类 细胞中 MAPK （mitogen -activated protein kinase， 丝裂原活化蛋白激酶） 信号通路 的另一亚类。 JNK 信号转导通路 是 MAPK 通路的一重要分支，它在 细胞周期 、生殖、凋亡和 细胞应激 等多种生理和 病理过程 中起重要作用。 JNK信号转导通路是1991年发现的一类MAPK通路。 JNK 蛋白激酶 由3个基因编码，jnk 1和jnk 2基因在全 …

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho、cdc42）的小分子 GTP 酶传递到这个级联。 和其他 MAPK 一样，膜近端激酶是一个 MAPKKK（通常为 MEKK1–4），或是混合性谱系激酶（MLK）中一员，能磷酸化并激活 MKK4 (SEK) 或 MKK7（即 SAPK/JNK 激酶）。 此外， MKK4/7 能由生发中心激酶 (GCK) 家族成员以独立于 …

Jan 1, 2025 · JNK1, rather than JNK2, causally contributes to TGF-β1-induced epithelial-to-mesenchymal transition (EMT) and pro-fibrotic gene expression, suggesting that JNK1 may be a promising target for pulmonary fibrosis treatment [7].

JNK 也称作 SAPKs（stress-activated protein kinases，应激激活的蛋白激酶），主要包括 JNK1（SAPKα，MAPK8）、JNK2（SAPKβ，MAPK9）、JNK3（SAPKγ，MAPK10）[1,3,5]。 JNK1、JNK2 在组织中广泛表达，而 JNK3 仅在脑、心和睾丸中表达 [2,5]。 JNK 磷酸化激活后可以作用下游多种转录因子（例如：Jun、Elk-1、Ets2等）与激酶（主要是MNK），产生促进生长、分化、存活、凋亡等多种生理效应 [1]。 活化的 JNK 能够磷酸化 c-Jun，其磷酸化位点位于 c …

Here we report that JNK1, but not JNK2, is essential for tumor necrosis factor alpha (TNF-α)-induced c-Jun kinase activation, c-Jun expression, and apoptosis. Using mouse fibroblasts deficient in either Jnk1 or Jnk2, we found that JNK1 was activated by TNF-α, whereas JNK2 activation was negligible.

Sep 10, 2004 · Different c-Jun N-terminal kinases (JNKs) are activated by a plethora of signals and phosphorylate substrates such as c-Jun, which is required for efficient cell cycle progression. Although JNK1 and JNK2 were shown to differentially regulate fibroblast proliferation, the underlying mechanistic basis …

JNK1 induces apoptosis, whereas JNK2 promotes carcinogenesis in an AP1-dependent manner. SCCA1 promotes SCC via inhibition of JNK1 and CYLD inhibits SCC via suppression of JNK2/AP1 cascade. In melanoma, the MALT1, MKK4/7, and JNK/AP1 signaling cascade promotes melanoma cell proliferation and migration, whereas CYLD inhibits it.

Mar 31, 2021 · Here we found that the germinal ablation of the MAPK c-Jun N-Terminal Kinase isoform 1 (JNK1) results in a significant reduction of myelin in the cerebral cortex and corpus callosum at both...

Mar 25, 1994 · Here, we describe the molecular cloning and characterization of JNK1, a distant relative of the MAP kinase group that is activated by dual phosphorylation at Thr and Tyr during the UV response. Significantly, Ha-Ras partially activates JNK1 …