2024年12月25日 · ITGB7 (Integrin Subunit Beta 7) is a Protein Coding gene. Diseases associated with ITGB7 include Inflammatory Bowel Disease 18 and T-Cell Non-Hodgkin Lymphoma. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Integrin β7 (ITGB7), which is expressed on the surface of leukocytes, plays an essential role in the homing of immune cells to gut-associated lymphoid tissue and facilitating the retention of lymphocytes in gut epithelium; however, its role in colorectal cancer pathogenesis is …

Expression of integrin beta-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.

2022年3月30日 · Chromatin immunoprecipitation and gene-regulatory network analyses both defined Itgb7 as an LRF target. Our study identifies LRF as an essential transcriptional regulator of IELp maturation in...

ITGB7 is a prognostic marker in Glioblastoma multiforme, Head and neck squamous cell carcinoma, Liver hepatocellular carcinoma, Ovary serous cystadenocarcinoma, Pancreatic adenocarcinoma

Purpose: We aimed to explore the prognostic value of integrin-β superfamily members (ITGBs) and their role in immune cell infiltration in non-small cell lung cancer (NSCLC). Materials and Methods: Study cases were acquired from The Cancer Genome Atlas …

2025年2月8日 · Orthologous to human ITGB7 (integrin subunit beta 7). [provided by Alliance of Genome Resources, Feb 2025] integrin beta-7, M290 IEL antigen, integrin beta-P. The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in …

2025年1月4日 · Title: Integrated analysis reveals the participation of IL4I1, ITGB7, and FUT7 in reshaping the TNBC immune microenvironment by targeting glycolysis.

The ITGB7 was the only ITGB family gene found in the 200 eccDNA genes. ITGB7 was enriched in focal adhesion, ECM-receptor interaction, the PI3K-Akt signaling pathway, and human papillomavirus infection.

Mechanistically, ITGB7 knockdown inhibited focal adhesion kinase (FAK) and Src phosphorylation, Rac1 activation, and SUMOylation, reduced VEGF production in MM–BM stem cell cocultures and attenuated p65-NF-κB activity.