2024年12月25日 · IRX3 (Iroquois Homeobox 3) is a Protein Coding gene. Diseases associated with IRX3 include Macular Dystrophy, Retinal, 3 and Cycloplegia . Among its related pathways is FTO obesity variant mechanism .

2021年9月23日 · Here we report that macrophage IRX3 promotes metabolic inflammation to accelerate the development of obesity and type 2 diabetes. Mice with myeloid-specific deletion of Irx3 were protected...

2014年3月12日 · Now, an international team of scientists has discovered that the obesity-associated elements within FTO interact with IRX3, a distant gene on the genome that appears to be the functional obesity gene. The FTO gene itself appears to have only a peripheral effect on obesity. The study appears online March 12 in Nature.

IRX3 and IRX5 Homeobox Genes are Effectors of FTO Obesity-Risk Variants. Iroquois homeobox (Irx) genes encode a family of highly conserved TALE homeodomain-containing transcription factors (TFs). Iroquois genes were first discovered in the fruit fly Drosophila melanogaster.

2021年9月23日 · In this issue of Nature Immunology, Qiu and colleagues identify the transcription factor IRX3 as a key driver of pro-inflammatory cytokine production in macrophages, which in mouse models is...

In 2014, the hypothalamic expression of Iroquois homeobox 3 (Irx3) gene was shown to regulate energy expenditure through the control of sympathetic outflow to the brown adipose tissue.

2018年12月9日 · In consonance with these results, authors demonstrate that not only full body but also hypothalamic-specific genetic deficiency in Irx3 expression leads to 30% weight loss, establishing Irx3 as a novel determinant of body mass and composition.

2022年7月26日 · Subsequently, we focused on Iroquois homeobox protein 3 (IRX3), one of 13 transcription factors that were screened from the 331 differentially expressed genes. The transcription factor IRX3 was significantly decreased in the liver tissue of patients with MAFLD when compared with healthy controls.

2011年10月14日 · In a recent article published in PNAS, Zhang et al identify an evolutionarily conserved role for the transcription factor Irx3 in regulating gap junction gene expression and fast propagation of electrical signal in the vertebrate ventricular conduction system.

Here we report that macrophage IRX3 promotes metabolic inflammation to accelerate the development of obesity and type 2 diabetes. Mice with myeloid-specific deletion of Irx3 were protected against diet-induced obesity and metabolic …