
IRX3 Gene - GeneCards | IRX3 Protein | IRX3 Antibody
2024年12月25日 · IRX3 (Iroquois Homeobox 3) is a Protein Coding gene. Diseases associated with IRX3 include Macular Dystrophy, Retinal, 3 and Cycloplegia . Among its related pathways …
Macrophage IRX3 promotes diet-induced obesity and …
2021年9月23日 · Here we report that macrophage IRX3 promotes metabolic inflammation to accelerate the development of obesity and type 2 diabetes. Mice with myeloid-specific deletion …
IRX3 is likely the fat gene - UChicago Medicine
2014年3月12日 · Now, an international team of scientists has discovered that the obesity-associated elements within FTO interact with IRX3, a distant gene on the genome that …
Irx3 and Irx5 - Novel Regulatory Factors of Postnatal …
IRX3 and IRX5 Homeobox Genes are Effectors of FTO Obesity-Risk Variants. Iroquois homeobox (Irx) genes encode a family of highly conserved TALE homeodomain-containing transcription …
The IRX(3)some factor in macrophages - Nature Immunology
2021年9月23日 · In this issue of Nature Immunology, Qiu and colleagues identify the transcription factor IRX3 as a key driver of pro-inflammatory cytokine production in macrophages, which in …
The partial inhibition of hypothalamic IRX3 exacerbates obesity
In 2014, the hypothalamic expression of Iroquois homeobox 3 (Irx3) gene was shown to regulate energy expenditure through the control of sympathetic outflow to the brown adipose tissue.
Irx3, a new leader on obesity genetics - PMC - National Center for ...
2018年12月9日 · In consonance with these results, authors demonstrate that not only full body but also hypothalamic-specific genetic deficiency in Irx3 expression leads to 30% weight loss, …
IRX3 plays an important role in the pathogenesis of metabolic ...
2022年7月26日 · Subsequently, we focused on Iroquois homeobox protein 3 (IRX3), one of 13 transcription factors that were screened from the 331 differentially expressed genes. The …
Irx3: A Conductor of Conduction | Circulation Research - AHA/ASA …
2011年10月14日 · In a recent article published in PNAS, Zhang et al identify an evolutionarily conserved role for the transcription factor Irx3 in regulating gap junction gene expression and …
Macrophage IRX3 promotes diet-induced obesity and …
Here we report that macrophage IRX3 promotes metabolic inflammation to accelerate the development of obesity and type 2 diabetes. Mice with myeloid-specific deletion of Irx3 were …
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