2024年12月25日 · IRX3 (Iroquois Homeobox 3) is a Protein Coding gene. Diseases associated with IRX3 include Macular Dystrophy, Retinal, 3 and Cycloplegia . Among its related pathways …

2021年9月23日 · Here we report that macrophage IRX3 promotes metabolic inflammation to accelerate the development of obesity and type 2 diabetes. Mice with myeloid-specific deletion …

2014年3月12日 · Now, an international team of scientists has discovered that the obesity-associated elements within FTO interact with IRX3, a distant gene on the genome that …

IRX3 and IRX5 Homeobox Genes are Effectors of FTO Obesity-Risk Variants. Iroquois homeobox (Irx) genes encode a family of highly conserved TALE homeodomain-containing transcription …

2021年9月23日 · In this issue of Nature Immunology, Qiu and colleagues identify the transcription factor IRX3 as a key driver of pro-inflammatory cytokine production in macrophages, which in …

In 2014, the hypothalamic expression of Iroquois homeobox 3 (Irx3) gene was shown to regulate energy expenditure through the control of sympathetic outflow to the brown adipose tissue.

2018年12月9日 · In consonance with these results, authors demonstrate that not only full body but also hypothalamic-specific genetic deficiency in Irx3 expression leads to 30% weight loss, …

2022年7月26日 · Subsequently, we focused on Iroquois homeobox protein 3 (IRX3), one of 13 transcription factors that were screened from the 331 differentially expressed genes. The …

2011年10月14日 · In a recent article published in PNAS, Zhang et al identify an evolutionarily conserved role for the transcription factor Irx3 in regulating gap junction gene expression and …

Here we report that macrophage IRX3 promotes metabolic inflammation to accelerate the development of obesity and type 2 diabetes. Mice with myeloid-specific deletion of Irx3 were …