Interferon regulatory factor 1 is a protein that in humans is encoded by the IRF1 gene. [4][5] Interferon regulatory factor 1 was the first member of the interferon regulatory transcription factor (IRF) family identified.

2024年12月25日 · IRF1 (Interferon Regulatory Factor 1) is a Protein Coding gene. Diseases associated with IRF1 include Immunodeficiency 117 and Gastric Cancer. Among its related pathways are Bacterial infections in CF airways and Overview of …

2021年1月21日 · Given the diverse array of effectors that exist in the IRF1 regulome, understanding the mechanisms underlying the protective role of IRF1 can be expected to provide key insights into microbial infections and host defense, as well as cancer biology where IRF1 also plays a pivotal role in disease outcome.

Innate immune signaling can induce the expression of interferon (IFN) regulatory factor 1 (IRF1), an important molecule in innate immune activation and cell death. While IRF1 has been shown to modulate some RCD pathways, a comprehensive evaluation of its role specifically in inflammatory cell death pathways is lacking.

irf1是最早发现的具备调节 干扰素 转录表达调控功能的高效调节因子。多年来并未完全揭示其在抗病毒天然免疫信号通路中的生物学功能。 多年来并未完全揭示其在抗病毒天然免疫信号通路中的生物学功能。

2023年10月27日 · We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings demonstrate that the loss of IRF1 from mouse HSCs significantly impairs self-renewal, increases stress-induced proliferation, and confers resistance to apoptosis.

2006年9月1日 · Four IRFs — IRF1, IRF3, IRF5 and IRF7 — have been implicated as positive regulators of the transcription of type I IFN genes 4,14. IRF1 was the first IRF-family member that was discovered to ...

2021年1月21日 · The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader …

编码的蛋白质激活参与机体对病毒和细菌反应的基因的转录，在细胞增殖、细胞凋亡、免疫反应和 DNA 损伤反应中发挥作用。 这种蛋白质抑制其他几个基因的转录。 作为肿瘤抑制因子，它既能抑制肿瘤细胞生长，又能刺激针对肿瘤细胞的免疫反应。 该基因的缺陷与胃癌、骨髓性白血病和肺癌有关。 [RefSeq 提供，2017 年 8 月] The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and …

我们发现巨噬细胞中的 TLR4 信号传导独特地与转录因子 IRF1 结合，从而促进 ISG 位点的转录开放。 这项研究为谱系特异性 TLR 反应提供了关键的机制基础，并揭示了 IRF1 作为人类巨噬细胞 ISG 转录程序的主要调节因子。 实验结果1. 对 TLR 信号传导的骨髓谱系特异性反应. 为了了解骨髓谱系特异性反应的基础，作者检查了定义从单核细胞分化为 MDM 或 MDDC 的轨迹的转录足迹。 作者从外周血单核细胞 (PBMC) 中分离出人单核细胞，并使用巨噬细胞集落刺激因子 (M …