Interleukin-1 receptor-associated kinase 3 is an enzyme that in humans is encoded by the IRAK3 gene. [5] [6] Using in vivo liposome-mediated delivery of CRISPR/Cas9 plasmid expressing IRAK3 gRNA, IRAK3 was shown to be responsible for endotoxin-induced expression of A20 and VE-cadherin in endothelial cells. Thus, IRAK3 is crucial for maintenance ...

2024年12月25日 · IRAK3 (Interleukin 1 Receptor Associated Kinase 3) is a Protein Coding gene. Diseases associated with IRAK3 include Asthma-Related Traits 5 and Multisystem Inflammatory Syndrome In Children. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and Toll Comparative Pathway.

IRAK3 is a critical modulator of inflammation in innate immunity. IRAK3 is associated with many inflammatory diseases, including sepsis, and is required in endotoxin tolerance to maintain homeostasis of inflammation.

2019年10月29日 · Interleukin-1 receptor associated kinase 3 (IRAK3) is a cytoplasmic homeostatic mediator of inflammatory responses and is potentially useful as a prognostic marker in inflammation. IRAK3...

2025年2月8日 · IRAK3 modulates downstream innate immune signalling through its guanylate cyclase activity. Findings demonstrated a distinctive role of IRAK-M in maintaining chronic Th2 airway inflammation and indicated a complex role for IRAK-M in the initiation and progression of experimental allergic asthma.

IRAK3 inhibitors work by modulating the activity of the IRAK3 protein, thereby influencing the downstream signaling pathways that control inflammation and immune responses. These inhibitors are designed to either block the expression of IRAK3 or inhibit its kinase activity, which is essential for its role in signaling pathways.

2016年8月22日 · IRAK3 has a well-established role in regulating innate immune responsiveness, mediating immune tolerance, and is a potent negative regulator of TLR/IL1R signaling. This post will attempt to elaborate on why we believe targeting IRAK3 is a differentiated, tractable, and worthwhile I/O strategy. Figure 1.

While IRAKs 4, 1 and 2 are, in most conditions, responsible for amplifying the signal from activated TLRs or IL-1Rs, the pseudokinase IRAK-M (also known as IRAK3) is a negative regulator of this response .

Interleukin-1 receptor-associated kinase-3 (IRAK3) is a critical checkpoint molecule of inflammatory responses in the innate immune system. The pseudokinase domain of IRAK3 contains a guanylate cyclase (GC) centre that generates small amounts of ...

2019年10月29日 · Interleukin-1 receptor associated kinase 3 (IRAK3) is a cytoplasmic homeostatic mediator of inflammatory responses and is potentially useful as a prognostic marker in inflammation. IRAK3 inhibits signalling cascades downstream of myddosome complexes associated with toll like receptors.