The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop.

CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007;27:10714–10721. doi: 10.1523/JNEUROSCI.1922-07.2007.

Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target ...

Aug 22, 2022 · Interleukin-4 (IL-4) CD4+T cells (Th2) synthesize IL-4, and it acts on both B and T cells. It is a B-cell growth factor and causes IgE and IgG1 isotype selection. It causes Th2 differentiation and proliferation, and it inhibits IFN gamma-mediated activation on macrophages. It promotes mast cell proliferation in vivo. Interleukin-5 (IL-5)

Keywords: alternative splicing, interelukin-4 receptor, interleukin-4 signaling, alternative macrophage activation. Abstract. Studies of IL-4 have revealed a wealth of information on the diverse roles of this cytokine in homeostatic regulation and disease pathogenesis.

Interleukin-4 is a cytokine that is produced by various cells and plays a role in exerting anti-inflammatory effects during infections like tuberculosis. AI generated definition based on: Tuberculosis, 2009

Jun 6, 2018 · Interleukin-4 and IL-13 are the signature cytokines of the type II inflammatory response. They are key players in the inflammatory response triggered either by an invading parasite or allergen.

5 days ago · Interleukin-4 (IL-4) is a key cytokine that regulates immune responses, particularly in allergic inflammation and adaptive immunity. It shapes T-helper cell differentiation, influences antibody production, and modulates signaling pathways. Given its broad impact, IL-4 has been extensively studied in both normal physiology and disease states.

Jul 19, 2005 · Interleukin-4 (IL-4) is a cytokine produced by T(H)2 type helper T cells and by mast cells, basophils, and eosinophils. This cytokine can elicit many responses, some of which are associated with allergy and asthma.

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4Rα chain and the common gamma chain (γc), resulting in a series of phosphorylation events mediated by receptor-associated kinases.