
白介素33的简介 - 知乎 - 知乎专栏
白介素33(interleukin 33,IL-33)是由人源基因 IL33编码的蛋白,其是IL-1家族成员,能有效驱动辅助因子Th2的产生。 白介素33是ST2的配体之一。 在非活性状态下,IL-33以前体形式(全长270个氨基酸残基),通过与染…
Interleukin 33 - Wikipedia
Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. [5] Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4). IL33 is a ligand for ST2 , an IL-1 family receptor that is highly expressed on Th2 cells, mast cells and group 2 innate ...
什么是白细胞介素33 (IL-33)? - 知乎
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IL33 Gene - GeneCards | IL33 Protein | IL33 Antibody
2024年12月25日 · Complete information for IL33 gene (Protein Coding), Interleukin 33, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Interleukin-33 in health and disease - Nature Reviews Immunology
2016年9月19日 · Il33 −/− mice with dextran sodium sulfate (DSS)-induced acute colitis showed decreased mortality and inflammation but had delayed recovery at later phases 154.
Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family
The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma. In this review, we highlight 15 years of discoveries on IL-33 protein, including its molecular characteristics, nuclear localization, bioactive forms, cellular ...
Interleukin-33 (IL-33): A critical review of its biology and the ...
2022年8月1日 · Cigarette smoke and infection are the major drivers of COPD. Loss of Il33 protects mice from smoke-induced exaggerated inflammatory responses to influenza virus infection, suggesting that IL-33 plays critical roles in pathogen-induced exacerbations of …
IL-33: Biological Properties, Functions and Roles in Airway Disease
IL-33 may be important for allergic airway diseases in humans. Indeed, the IL33 and ST2/IL1RL1 genes were found to be associated with asthma and allergic rhinitis in several GWAS studies that included thousands of human subjects from diverse ethnic groups (29–33, 127). Below, we have discussed the studies that investigated the potential roles ...
Interleukin-33 (IL-33): A critical review of its biology and the ...
Analysis of patient samples and studies in murine models support an important role of IL-33/ST2 signaling in allergic inflammation in different tissues (lung, nasopharynx, skin) and diseases (asthma, chronic rhinosinusitis, allergic rhinitis, atopic dermatitis). IL33 and IL1RL1/ST2 are among the most highly replicated susceptibility loci for ...
领异标心 | IL-33在癌症中的作用:最新进展和未来展望
2022年9月16日 · 若要将IL33/ST2最大限度运用到肿瘤诊断及治疗,关键在于肿瘤微环境的研究及如何平衡其在Th1/Th2免疫应答中的作用,这或将成为未来肿瘤研究的关注点。