IL-31 is a critical cytokine involved in neuroimmune communication, which opens new avenues for cytokine modulation in neuroinflammatory diseases including AD/pruritus, as validated by …

IL-31 is a critical cytokine involved in neuroimmune communication, which opens new avenues for cytokine modulation in neuroinflammatory diseases including AD/pruritus, as validated by …

Like other IL-6 family cytokines, IL-31 is an anti-parallel four-helix bundle, with an “up-up-down-down” topology in short chains, with an early form composed of 164 amino acids (aa) and a …

IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed …

Recently, Interleukin (IL)-31 and its receptor complex attracted significant interest, as clinical phase two studies demonstrated therapeutic efficacy of the neutralizing IL-31 receptor A (IL …

IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, …

IL-31 acts on a broad range of immune- and non-immune cells and therefore possesses potential pleiotropic physiological functions, including regulating hematopoiesis and immune response, …

Dec 25, 2024 · IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is …

Dec 16, 2024 · Nemolizumab-ilto is a humanized IgG2 monoclonal antibody that selectively binds to the interleukin (IL)-31 receptor A (RA) to inhibit IL-31 signaling. IL-31 is a naturally occurring …

We find that IL-31 receptor expression is dependent on STAT3 in sensory neurons. In addition, pharmacological experiments suggest that STAT3 activation is important for the itch-inducing …

IL-31 is a 24 kDa four-helix bundle belonging to the IL-6/gp130 family that binds to the heterodimeric IL-31Rα/oncostatin M receptor-β receptor. You might find these chapters and …

IL-31 signals through a receptor complex consisting of IL-31 receptor α and oncostatin M receptor β. The available data show that IL-31 is strongly linked with chronic pruritic skin disorders, …

Oct 13, 2023 · In a mouse model of chronic house dust mite–induced dermatitis, Fassett et al. found that IL-31 restrains cutaneous type 2 inflammation by initiating a pathway of neurogenic …

IL-31 and IL-33 are still considered novel cytokines. IL-31 controls signalling and regulates a huge amount of biological functions: it induces proinflammatory cytokines, regulates cell …

Apr 29, 2024 · Introduction Interleukin-31 (IL-31) stands at the intersection of immunology and inflammation, playing a crucial role in various inflammatory conditions. In this blog post, we …

Jun 10, 2022 · The results showed that IL-31 plays a crucial role in the pathogenesis of systemic skin manifestations, prognosis, and itch severity. Traditional therapies target this interleukin …

IL-31 is mainly produced by CD4 + helper T cells and transmits the signals via a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor (OSMR), both of …

Jun 10, 2022 · Interleukin 31 belongs to the IL-6 superfamily, and it is an itch mediator already studied in several diseases, comprising atopic dermatitis, allergic pathologies, and onco …

Feb 8, 2025 · Interleukin-31, a Potent Pruritus-Inducing Cytokine and Its Role in Inflammatory Disease and in the Tumor Microenvironment. Upregulation of interleukin (IL)-31, a cytokine …

Nov 25, 2021 · IL-31 is mainly produced by CD4+ helper T cells and transmits the signals via a heterodimeric receptor composed of IL-31 receptor A (IL-31RA) and oncostatin M receptor …