
Inhibition of IL-11 signalling extends mammalian healthspan and ...
2024年7月17日 · Deletion of Il11 or Il11ra1 protects against metabolic decline, multi-morbidity and frailty in old age. Administration of anti-IL-11 to 75-week-old mice for 25 weeks improves metabolism and...
Understanding interleukin 11 as a disease gene and therapeutic …
Interleukin 11 (IL11) is an elusive member of the IL6 family of cytokines. While initially thought to be a haematopoietic and cytoprotective factor, more recent data show instead that IL11 is redundant for haematopoiesis and toxic.
Interleukin-11: Review of Molecular, Cell Biology, and Clinical …
1997年6月1日 · Initially characterized as a hematopoietic cytokine with thrombopoietic activity, IL-11 has now been shown to be expressed and have activity in multiple other tissues, including brain, spinal cord neurons, gut, and testis. Yet to date, the …
IL-11 is a crucial determinant of cardiovascular fibrosis
2017年12月7日 · Here we show, using integrated imaging-genomics analyses of primary human fibroblasts, that upregulation of interleukin-11 (IL-11) is the dominant transcriptional response to TGFβ1 exposure and required for its pro-fibrotic effect.
IL11 Gene - GeneCards | IL11 Protein | IL11 Antibody
2024年12月25日 · IL11 (Interleukin 11) is a Protein Coding gene. Diseases associated with IL11 include Hemorrhagic Cystitis and Plasmacytoma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-11 receptor binding.
Interleukin-11-expressing fibroblasts have a unique gene ... - Nature
2021年4月16日 · IL-11 induces the activation of colonic fibroblasts and epithelial cells through phosphorylation of STAT3. Human cancer database analysis reveals that the expression of genes enriched in IL-11...
IL11 interleukin 11 [Homo sapiens (human)] - Gene - NCBI
2025年2月8日 · Title: Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway. IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFbeta.
Interleukin-11 signaling underlies fibrosis, parenchymal dysfunction ...
2020年12月1日 · Interleukin (IL)-11 evolved as part of the innate immune response. In the human lung, IL-11 upregulation has been associated with viral infections and a range of fibroinflammatory diseases,...
IL-11/IL11RA receptor mediated signaling: a web accessible ...
Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. It plays a significant role in the synthesis and maturation of hematopoietic cells, inhibition of adipogenesis, regulation of embryo implantation, and trophoblasts invasion.
Interleukin-11 signaling promotes cellular reprogramming and …
Deep phenotyping and transcriptional analysis of adult hearts and fins show that Il-11 signaling drives cellular reprogramming to orchestrate global and tissue-specific regenerative programs and broadly antagonizes hallmarks of adult mammalian scarring.
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