Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. [4] [5] [6] IL-13 was first cloned in 1993 and is located on chromosome 5q31.1 with a length of 1.4kb. [4] It has a mass of 13 kDa and folds into 4 alpha helical bundles. [7]

Interleukin 13 (IL-13) is a cytokine that is responsible for promoting Th2 responses in humans and is released by T cells, mast cells, and eosinophils. It is typically associated with allergic inflammation, including asthma, but it also plays a role in fibrosis pathogenesis.

IL-13 is a cytokine that is produced by different T-cell subsets and dendritic cells. IL-13 shares many biologic activities with IL-4. This is due to the fact that IL-13– and IL-4–receptor complexes share the IL-4–receptor α-chain, which is important for signal transduction. T cells do not express functional IL-13 receptors.

2023年1月13日 · We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, and human brains, whose engagement upregulates the phosphorylation of NMDAR and AMPAR...

IL-13 is involved in the processes contributing to the transition from metabolic-dysfunction-associated steatosis to MASH. IL-13 is a Th2-specific cytokine that induces the alternative activation of macrophages, thereby counteracting Th1-driven inflammatory processes.

IL-13 was first recognized for its effects on B cells and monocytes, where it upregulated class II expression, promoted IgE class switching and inhibited inflammatory cytokine production. It was also thought to be functionally redundant with IL-4.

This review provides an update on the role of IL-13 in AD and discusses the different strategies aimed at interfering with its biologic activity as well as their potential in a precision medicine approach in the management of AD.

Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to induce activation responses which contribute to the inflammatory diseases. Genetic polymorphisms in IL-13 and its receptor components have been proved to be associated with higher disease prevalence rates.

2019年12月5日 · IL-13 is a pleiotropic cytokine originally cloned from activated human T-lymphocytes (Minty et al., 1993). The human IL13 gene is located on chromosome 5q31-33 in the cluster of genes encoding IL-4, IL-3, IL-5, IL-9, and granulocyte-macrophage colony-stimulating factor (GM-CSF).

Over the past several years, it has become evident that IL-13 is a key mediator in the pathogenesis of allergic inflammation. IL-13 shares many functional properties with IL-4, stemming from the fact that they share a common receptor subunit, the α subunit of the IL-4 receptor (IL-4Rα).