Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene. [5][6][7] This gene encodes a member of the Ikaros family of zinc-finger proteins.

2024年12月25日 · IKZF3 (IKAROS Family Zinc Finger 3) is a Protein Coding gene. Diseases associated with IKZF3 include Immunodeficiency 84 and Leukemia, Chronic Lymphocytic. Among its related pathways are IL2 signaling events mediated by STAT5 and 17q12 copy number variation syndrome.

2024年1月5日 · Using conditional genetic inactivation, we show that Ikzf1 /Ikaros is essential for normal natural killer (NK) cell lymphopoiesis and IKZF1 directly represses Cish, a negative regulator of...

2021年3月8日 · Hotspot mutation of IKZF3 (IKZF3-L162R) has been identified as a putative driver of chronic lymphocytic leukemia (CLL), but its function remains unknown. Here, we demonstrate its driving role in CLL through a B cell-restricted conditional knockin mouse model.

2025年2月8日 · IKZF3 is a novel prognostic biomarker for head and neck squamous cell carcinoma: A study based on bioinformatics analysis. IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target.

2020年11月5日 · A hotspot mutation within the DNA-binding domain of IKZF3 (IKZF3-L162R) has been identified as a putative driver in chronic lymphocytic leukemia (CLL); however, its functional effects are unknown. We recently confirmed its role as a CLL driver in a B cell-restricted conditional knock-in model.

Exons 4–6 harbor four zinc fingers that bind DNA and the C-terminus of exon 8 contains two zinc fingers that mediate homodimerization of Ikaros and heterodimerization with other Ikaros family members such as Aiolos (IKZF3).

IKZF3 is a prognostic marker in Bladder urothelial carcinoma, Head and neck squamous cell carcinoma, Lung adenocarcinoma

2024年11月2日 · Title: IKZF3 is a novel prognostic biomarker for head and neck squamous cell carcinoma: A study based on bioinformatics analysis. IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target.

2024年5月17日 · This study reports a mutation in the third DNA-binding zinc finger region of IKZF3 for the first time, and this de novo IKZF3 mutation provides insights into the molecular mechanisms of AIOLOS in immune function.