Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene. [ 5 ] [ 6 ] [ 7 ] This protein is a member of Ikaros family of transcription factors. [ 8 ]

2024年12月25日 · IKZF2 (IKAROS Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with IKZF2 include Otitis Media and Leukemia, Acute Lymphoblastic . Gene …

2025年2月8日 · Identification of germline monoallelic mutations in IKZF2 in patients with immune dysregulation. Loss-of-function mutation in IKZF2 leads to immunodeficiency with …

This study, based on a large clinical cohort, found that IKZF2, an essential transcription factor during T cell development and differentiation, showed stage-dependent overexpression in the …

2023年4月10日 · Degradation of IKZF2 and CK1α blocks cell growth and induces myeloid differentiation in AML cells through CK1α-p53- and IKZF2-dependent pathways. Target …

2019年1月3日 · IKZF2 is highly expressed in leukemic stem cells (LSCs), and its deficiency results in defective LSC function. IKZF2 depletion in acute myeloid leukemia (AML) cells …

2022年11月15日 · To determine the contribution of CK1α and IKZF2 to the cellular phenotypes in MOLM13 cells, we developed CK1α and IKZF2 nondegradable mutants. CK1α, G40N was …

2024年12月10日 · Title: Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. Germline biallelic …

2019年10月15日 · Terminal Effector CD8 T Cells Defined by an IKZF2 + IL-7R-Transcriptional Signature Express FcγRIIIA, Expand in HIV Infection, and Mediate Potent HIV-Specific …

2023年3月16日 · Malignant tumors can evade destruction by the immune system by attracting immune-suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor …