2024年12月25日 · IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) is a Protein Coding gene. Diseases associated with IGF2BP3 include Langerhans Cell Sarcoma and Keratoacanthoma. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind …

研究者敲降了细胞的igf2bp3，检测mrna稳定性，发现igf2bp3和clip的高可信度靶基因的中位半衰期都显著缩短了将近一半！ 还有哪些因子共同增强mRNA的稳定性呢？

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene. [ 5 ] [ 6 ] [ 7 ] The protein encoded by this gene is primarily found in the nucleolus , where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II ...

2023年12月13日 · 通过敲低实验以及靶向结合实验证明， IGF2BP3 是调控 m 6 A 介导的 mRNA 在多聚核糖体和 P-body 中分布的主要因子。 基于该工作的研究结果，研究人员提出 m 6 A-IGF2BP3 通过调控 mRNA 在多聚核糖体和 P-body 中的分布，从而调控了 mRNA 的翻译（图 …

2024年8月28日 · Here the authors show that the binding of IGF2BP1-3, especially IGF2BP3, with m7G, could promote the degradation of m7G target transcripts in cancer cells.

2025年2月9日 · IGF2BP3 Worsens Lung Cancer through Modifying Long Non-coding RNA CERS6-AS1/microRNA-1202 Axis. IGF2BP3 overexpression predicts poor prognosis and correlates with immune infiltration in bladder cancer. STRIP2 motivates non-small cell lung cancer progression by modulating the TMBIM6 stability through IGF2BP3 dependent.

2023年10月18日 · Our findings highlight the pro-metastatic function of the IGF2BP3/Notch3 axis and revealed the precise role of IGF2BP3 in post-transcriptional regulation of NOTCH3, suggesting IGF2BP3 as a...

5 天之前 · Importantly, IGF2BP3 promoted HCC cells progression in an m6A-dependent manner, IGF2BP3 silencing significantly inhibited proliferation and migratory ability of tumor cells in vitro and in in vivo.

2020年1月15日 · Among the RBPs, insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is of particular interest in tumorigenesis and tumor progression. This review highlights the molecular mechanisms underlying the oncogenic functions of IGF2BP3, summarizes the therapeutic potential related to its inhibition and notes the fundamental issues that remain ...

胰岛素样生长因子 2 mrna 结合蛋白 3： 由该基因编码的蛋白质主要存在于核仁中，在那里它可以与胰岛素样生长因子 ii 前导 3 mrna 的 5' utr 结合，并可能在后期发育过程中抑制胰岛素样生长因子 ii 的翻译。编码的蛋白质包含几个 kh 结构域，这些结构域在 rna 结合中很重要，并且已知参与 rna …