Immunoglobulin A - Wikipedia
IgA exists in two isotypes, IgA1 and IgA2. They are both heavily glycosylated proteins. [ 9 ] While IgA1 predominates in serum (~80%), IgA2 percentages are higher in secretions than in serum …
IgA subclasses have different effector functions associated with ...
Jan 8, 2020 · Here, we show that the two IgA subclasses (IgA1 and IgA2) differ in their effect on immune cells due to distinct binding and signaling properties. Whereas IgA2 acts pro …
IgA: Structure, Function, and Developability - PMC
In humans, there are two subclasses of IgA, named IgA1 and IgA2. Like all Ig, each subclass comprises a basic molecular unit of two identical heavy chains (HCs) and two identical light …
Immunoglobulin A (IgA) – Structure, Properties, Subclasses, …
Jan 23, 2024 · IgA2. IgA2 comprises 15% of total IgA in serum and plays a crucial role in the mucosa of the eyes, airways and the gastrointestinal tract to fight against polysaccharide and …
IgA subclasses have different effector functions associated with ...
Jan 8, 2020 · Here, we show that the two IgA subclasses (IgA1 and IgA2) differ in their effect on immune cells due to distinct binding and signaling properties. Whereas IgA2 acts pro …
Immunoglobulin A (IgA)- Structure, Subclasses and Functions
Jun 25, 2022 · IgA2 – IgA2, represents only up to 15% of total IgA in serum, but IgA2 percentages are higher in secretions. – Plays a crucial role in the mucosa of the airways, eyes and the …
Immunoglobulin IgA Class | Thermo Fisher Scientific - US
IgA2. IgA2, representing only up to 15% of total IgA in serum, plays a crucial role in the mucosa of the airways, eyes and the gastrointestinal tract to fight against polysaccharide and …
Structure and function relationships in IgA - Mucosal Immunology
Sep 21, 2011 · Here, we provide an overview of human IgA structure, describing the distinguishing features of the IgA1 and IgA2 subclasses and mapping the sites of interaction …
Biochemistry, Immunoglobulin A - StatPearls - NCBI Bookshelf
May 1, 2023 · Immunoglobulin A (IgA), one of the five primary immunoglobulins, plays a pivotal role in mucosal homeostasis in the gastrointestinal, respiratory, and genitourinary tracts, …
Immunoglobulin A Glycosylation and Its Role in Disease
Human IgA is comprised of two subclasses, IgA1 and IgA2. Monomeric IgA (mIgA), polymeric IgA (pIgA), and secretory IgA (SIgA) are the main molecular forms of IgA. The production of IgA …