Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in humans is encoded by the IRF8 gene.

DCs分为 DC1s 和 DC2s， DC1s的分化依赖于转录调节因子 IRF8，呈递外源性抗原给CTLs； DC2s分化依赖于IRF4，调节CD4+ T细胞。 在一些肿瘤模型中，DC1s的消减损害了癌细胞反应性CTL的启动。 （二）肿瘤组织相关APC功能， 单核细胞-巨噬细胞系在浸润到肿瘤的白细胞中占很大比例，并与抑制CTL反应有关，与多种肿瘤类型的患者预后不佳有关。 单核细胞和巨噬细胞影响CTL可能通过以下方式： 通过不同代谢新陈活动抑制CTL生长：包括精氨酸剥夺、活性氧产 …

2024年12月25日 · IRF8 (Interferon Regulatory Factor 8) is a Protein Coding gene. Diseases associated with IRF8 include Immunodeficiency 32A and Immunodeficiency 32B. Among its related pathways are Antiviral mechanism by IFN-stimulated genes and Cytokine Signaling in Immune system.

Here we show that interferon regulatory factor 8 (IRF8) is essential for efficient activation of STING-mediated innate immune responses in monocytes. This function of IRF8 is independent of its transcriptional role in monocyte differentiation.

IRF8 is a Reliable Monoblast Marker for Acute Monocytic Leukemias. PU.1 and IRF8 Modulate Activation of NLRP3 Inflammasome via Regulating Its Expression in Human Macrophages. Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.

干扰素共有序列结合蛋白 (ICSBP) 是干扰素 (IFN) 调节因子 (IRF) 家族的转录因子。 该家族的蛋白质由 N 末端区域中的保守 DNA 结合域和作为调节域的不同 C 末端区域组成。 IRF 家族蛋白与 IFN 刺激的反应元件 (ISRE) 结合并调节 I 型 IFN 刺激的基因表达，即 IFN-α 和 IFN-β。 IRF 家族蛋白还控制由病毒感染诱导的 IFN-α 和 IFN-β 调节基因的表达。 [RefSeq 提供，2008 年 7 月]

2020年3月30日 · The transcription factor IRF8 (ICSBP) is required for the development and maturation of myeloid cells (dendritic cells, monocytes, macrophages), and for expression of intrinsic anti-microbial function such as antigen capture, processing and presentation to lymphoid cells, and for activation of these cells in response to cytokines and pro ...

2006年9月1日 · IRF8, another immune-cell-specific member of the IRF family, is also involved in the TLR9–MyD88 pathway . IRF8 increases signalling by interacting with, and activating, TRAF6 (Ref. 98).

2024年12月10日 · Title: Expression of Interferon Regulatory Factor 8 (IRF8) and Its Association with Infections in Dialysis Patients. Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF.

2022年8月24日 · Interferon regulatory factor 8 (IRF8) is a transcription factor of the IRF protein family. IRF8 was originally identified as an essentialfactor for myeloid cell lineage commitment and differentiation.